CAJ | 학술논문

目的：探讨2型糖尿病（T2DM）患者夜间低氧与血糖的关系及无创通气治疗对2型糖尿病合并睡眠呼吸暂停低通气综合征（OWD）患者昼夜血糖的影响。方法对750例 T2DM 打鼾患者进行夜间脉搏-氧饱和度监测，根据夜间出现低氧情况分为夜间低氧组（484例）与无夜间低氧组（266例），对两组患者年龄、体质指数（BMI）、颈围、腹围、空腹血糖（FBG）进行分析，并对7例 OWD 患者进行睡眠监测、脉搏血氧监测及96 h 动态血糖监测（CGMS），呼吸机无创通气治疗48 h 前后，比较 OWD 患者昼夜血糖变化。结果夜间低氧组和夜间无低氧组 BMI 分别为（27．2±4．8）、（25．5±3．0）kg／m2，颈围分别为（36．7±3．8）、（35．7±3．0）cm，腰围分别为（94．3±11．5）、（89．1±11．1）cm，空腹血糖分别为（6．9±2．4）、（6．5±2．0）mol／L，组间差异均有统计学意义（P ＜0．05）。7例 OWD 患者无创通气治疗前后，昼夜动态动态血糖水平差异有统计学意义（P ＜0．05）。结论T2DM 患者空腹血糖与夜间低氧相关，无创通气治疗可以降低 OWD 患者昼夜血糖水平。
목적：탐토2형당뇨병（T2DM）환자야간저양여혈당적관계급무창통기치료대2형당뇨병합병수면호흡잠정저통기종합정（OWD）환자주야혈당적영향。방법대750례 T2DM 타한환자진행야간맥박-양포화도감측，근거야간출현저양정황분위야간저양조（484례）여무야간저양조（266례），대량조환자년령、체질지수（BMI）、경위、복위、공복혈당（FBG）진행분석，병대7례 OWD 환자진행수면감측、맥박혈양감측급96 h 동태혈당감측（CGMS），호흡궤무창통기치료48 h 전후，비교 OWD 환자주야혈당변화。결과야간저양조화야간무저양조 BMI 분별위（27．2±4．8）、（25．5±3．0）kg／m2，경위분별위（36．7±3．8）、（35．7±3．0）cm，요위분별위（94．3±11．5）、（89．1±11．1）cm，공복혈당분별위（6．9±2．4）、（6．5±2．0）mol／L，조간차이균유통계학의의（P ＜0．05）。7례 OWD 환자무창통기치료전후，주야동태동태혈당수평차이유통계학의의（P ＜0．05）。결론T2DM 환자공복혈당여야간저양상관，무창통기치료가이강저 OWD 환자주야혈당수평。
Objective To study the relationship of nocturnal oxygen desaturation and blood sugar level,and the effects noninvasive ventilation(NIV)therapy on the blood sugar level of OWD.Methods 750 snoring patients were received the nocturnal oxygen desaturation test.According the test results,the 750 patients were divided into:the normal and the low nocturnal oxygen desaturation group,to compare the BMI,neck circumference,abdominal circumference and the blood sugar.The blood sugar level were measured and compared before and after the nocturnal NIV therapy.Results The results showed:(1)There were sig-nificant differences between the normal and the low nocturnal oxygen desaturation group on the body mass [(27.2±4.8)kg/m2 vs.(25.5±3.9)kg/m2 ],neck circumference [(36.7±3.8)cm vs.(35.7±3.0)cm],ab-dominal circumference [(94.3±11.5)cm vs.(89.1±11.1)cm]and blood sugar [(6.9±2.4)mmol/L vs. (6.5±2.0)mmol/L]respectively;(2)The blood sugar level of the OWD patient were significantly de-creased after the nocturnal NIV therapy (P <0.05 vs none therapy).Conclusion The nocturnal oxygen desaturation is closely related to the blood sugar level of Type 2 diabetes mellitus patients,and the short-term NIV therapy can reduce the blood sugar level of OWD patients.