CAJ | 학술논문

目的：观察血管内皮生长因子( Vascular endothelial growth factor,VEGF)与整合素连接激酶( Integrin-linked kinase,ILK)在涎腺腺样囊性癌( Salivary adenoid cystic carcinoma,SACC)中的定位及表达,探讨VEGF与ILK在SACC中的作用,揭示SACC的发病机制.方法对30例SACC存档蜡块行免疫组化分析,观察VEGF与ILK在SACC中的表达分布情况.利用SPSS 13.0统计软件分析VEGF与ILK的差异性及相关性.结果在SACC中, VEGF阳性率为83.33%,ILK阳性率为76.67%；VEGF实验组与对照组比较,P<0.05,ILK实验组与对照组比较, P<0.05；VEGF与ILK在SACC中的表达存在正相关,r=0.388.结论在SACC的发生发展过程中,血管生成是其发生的重要步骤,血管的生长速率是其侵袭和转移的条件. VEGF与ILK在血管的生成过程中起着重要的作用, VEGF与ILK在SACC中的表达存在正性相关,它们共同作用于SACC的血管生成,影响SACC血管生长的速率.
목적：관찰혈관내피생장인자( Vascular endothelial growth factor,VEGF)여정합소련접격매( Integrin-linked kinase,ILK)재연선선양낭성암( Salivary adenoid cystic carcinoma,SACC)중적정위급표체,탐토VEGF여ILK재SACC중적작용,게시SACC적발병궤제.방법대30례SACC존당사괴행면역조화분석,관찰VEGF여ILK재SACC중적표체분포정황.이용SPSS 13.0통계연건분석VEGF여ILK적차이성급상관성.결과재SACC중, VEGF양성솔위83.33%,ILK양성솔위76.67%；VEGF실험조여대조조비교,P<0.05,ILK실험조여대조조비교, P<0.05；VEGF여ILK재SACC중적표체존재정상관,r=0.388.결론재SACC적발생발전과정중,혈관생성시기발생적중요보취,혈관적생장속솔시기침습화전이적조건. VEGF여ILK재혈관적생성과정중기착중요적작용, VEGF여ILK재SACC중적표체존재정성상관,타문공동작용우SACC적혈관생성,영향SACC혈관생장적속솔.
Objective To explore the expression of VEGF and ILK in SACC by IHC, to analyze the roles of VEGF and ILK and their correlation in SACC,and to reveal the pathogenesis of SACC. Method IHC was used to determine the expression of VEGF and ILK in 30 cases of SACC. The correlation of VEGF and ILK was statistically analyzed by SPSS. Results The positive rate of VEGF was 83. 33%,the positive rate of ILK was 76. 67%. Differences between the experimental group of VEGF and the control group were significant(P<0. 05), and differences between the experimental group of ILK and the control group were significant ( P<0 . 05 ) . The expression of VEGF was positively correlated with ILK expression in SACC,r=0. 388. Conclusion VEGF and ILK play a role in promoting the growth of SACC and tumor angiogenesis. In the development of SACC, angiogenesis is an important step, and vascular growth rate is the condition of invasion and metastasis. The expression of VEGF and ILK in SACC shows a positive correlation. They collaborate on angiogenesis and growth rate of blood vessel.