国际生殖健康计划生育杂志
國際生殖健康計劃生育雜誌
국제생식건강계화생육잡지
Journal of International Reproductive Health/Family Planning
2015年
1期
75-79
,共5页
吴夏迪%曲娟%崔毓桂%冒韵东
吳夏迪%麯娟%崔毓桂%冒韻東
오하적%곡연%최육계%모운동
子宫内膜异位症%遗传学%CpG岛%甲基化%芳香酶
子宮內膜異位癥%遺傳學%CpG島%甲基化%芳香酶
자궁내막이위증%유전학%CpG도%갑기화%방향매
Endometriosis%Genetics%CpG islands%Methylation%Aromatase
子宫内膜异位症(EMs)是一种雌激素依赖的炎性疾病,发病机制尚不清楚。越来越多的证据表明,一些基因的表观遗传学特性与EMs的发病有关。表观遗传学是指DNA序列不发生变化,但基因表达却发生了可遗传的改变,包括DNA甲基化、组蛋白共价修饰及染色质构象变化,这些改变可能会引发一系列包括肿瘤在内的病理变化。 EMs异位组织中芳香化酶基因的CpG岛序列低甲基化和(或)反式作用因子上调芳香化酶基因的表达;卵巢异位上皮及间质细胞的雌激素受体α(ERα)低表达而ERβ显著高表达;在位细胞的孕激素受体α(PRα)和PRβ均高表达;EMs异位内膜细胞的类固醇生成因子1(SF-1)启动子低甲基化而在位内膜高甲基化。此外,EMs异位组织E-钙黏蛋白(E-cadherin)基因及在位组织同源框基因A10(HOXA10)表达降低也与EMs有关;环境因素可能会影响表观遗传基因导致EMs的发生。综述表观遗传学改变和环境因素在EMs发病中的作用。
子宮內膜異位癥(EMs)是一種雌激素依賴的炎性疾病,髮病機製尚不清楚。越來越多的證據錶明,一些基因的錶觀遺傳學特性與EMs的髮病有關。錶觀遺傳學是指DNA序列不髮生變化,但基因錶達卻髮生瞭可遺傳的改變,包括DNA甲基化、組蛋白共價脩飾及染色質構象變化,這些改變可能會引髮一繫列包括腫瘤在內的病理變化。 EMs異位組織中芳香化酶基因的CpG島序列低甲基化和(或)反式作用因子上調芳香化酶基因的錶達;卵巢異位上皮及間質細胞的雌激素受體α(ERα)低錶達而ERβ顯著高錶達;在位細胞的孕激素受體α(PRα)和PRβ均高錶達;EMs異位內膜細胞的類固醇生成因子1(SF-1)啟動子低甲基化而在位內膜高甲基化。此外,EMs異位組織E-鈣黏蛋白(E-cadherin)基因及在位組織同源框基因A10(HOXA10)錶達降低也與EMs有關;環境因素可能會影響錶觀遺傳基因導緻EMs的髮生。綜述錶觀遺傳學改變和環境因素在EMs髮病中的作用。
자궁내막이위증(EMs)시일충자격소의뢰적염성질병,발병궤제상불청초。월래월다적증거표명,일사기인적표관유전학특성여EMs적발병유관。표관유전학시지DNA서렬불발생변화,단기인표체각발생료가유전적개변,포괄DNA갑기화、조단백공개수식급염색질구상변화,저사개변가능회인발일계렬포괄종류재내적병리변화。 EMs이위조직중방향화매기인적CpG도서렬저갑기화화(혹)반식작용인자상조방향화매기인적표체;란소이위상피급간질세포적자격소수체α(ERα)저표체이ERβ현저고표체;재위세포적잉격소수체α(PRα)화PRβ균고표체;EMs이위내막세포적류고순생성인자1(SF-1)계동자저갑기화이재위내막고갑기화。차외,EMs이위조직E-개점단백(E-cadherin)기인급재위조직동원광기인A10(HOXA10)표체강저야여EMs유관;배경인소가능회영향표관유전기인도치EMs적발생。종술표관유전학개변화배경인소재EMs발병중적작용。
Endometriosis(EMs), an estrogen-dependent inflammatory disease, is still unclear in pathogenesis. More and more evidence proved that epigenetic characteristics of several genes were associated with EMs. Epigenetics is referred to the heritable genetic changes such as DNA methylation, histone covalent modification and chromatin conformation changes, which do not change DNA sequence. Epigenetic abnormality may trigger a series of pathological disorders including tumors. Hypomethylation of CpG islands in aromatase gene and (or) trans-acting factor genes up-regulated the expression of aromatase mRNA in the ectopic tissues. Low expression of ERα and significantly high expression of ERβ were found in the ovarian ectopic epithelial and stromal cells, while high expressions of both PRα and PRβ in the eutopic cells. The promoter of steroidgenic factor-1 (SF-1) was hypomethylation in ectopic cells, while it was hypermethylation in eutopic cells. In addition, the decreased expressions of both E-cadherin gene in ectopic tissues and homeobox A10 gene in eutopic tissues were also related to EMs. Environmental factors may be involved in EMs by epigenetic mechanism. This review summarized the roles of epigenetics and environmental factors in the pathogenesis of EMs.