CAJ | 학술논문

目的：利用已发表文献，采用荟萃分析方法分析我国育龄妇女受教育程度与其对叶酸补充的认知及服用情况的关系。方法：分别在Pubmed采用“folic acid”、“pregnancy”和“China”等关键词组合进行检索；在中国生物医学文献服务系统（Sinomed）、中国期刊全文数据库（CNKI）、维普中文期刊全文数据库（VIP）等数据库中采用“叶酸”、“妇女”等关键词组合检索相关文献，检索所有2014年4月19日及此前的相关文献，并对文章的参考文献也进行了检索。纳入标准为：观察性研究；包含受教育程度与育龄妇女对叶酸补充的认知或服用关系信息；研究对象为中国育龄妇女。结果：共获得中英文全文文献436篇，其中中文339篇、英文97篇。最终纳入符合标准的文献15篇。采用随机效应模型进行荟萃分析，以受教育水平为初中及以下者为对照，其余调查对象知晓叶酸的OR值及其95%CI分别为：高中/中专2.12（1.65，2.72）、大学及以上6.24（4.24，9.19）；调查对象服用叶酸的OR值及其95%CI分别为：高中/中专1.63（1.39，1.93）、大学及以上3.48（2.35，5.16），差异均有统计学意义。结论：我国育龄妇女受教育水平与其对叶酸的认知及服用叶酸有关。应重点加强受教育水平较低的育龄妇女对叶酸的认知和正确服用的相关教育，以进一步降低新生儿神经管畸形发生的概率，提高我国母婴健康水平。
목적：이용이발표문헌，채용회췌분석방법분석아국육령부녀수교육정도여기대협산보충적인지급복용정황적관계。방법：분별재Pubmed채용“folic acid”、“pregnancy”화“China”등관건사조합진행검색；재중국생물의학문헌복무계통（Sinomed）、중국기간전문수거고（CNKI）、유보중문기간전문수거고（VIP）등수거고중채용“협산”、“부녀”등관건사조합검색상관문헌，검색소유2014년4월19일급차전적상관문헌，병대문장적삼고문헌야진행료검색。납입표준위：관찰성연구；포함수교육정도여육령부녀대협산보충적인지혹복용관계신식；연구대상위중국육령부녀。결과：공획득중영문전문문헌436편，기중중문339편、영문97편。최종납입부합표준적문헌15편。채용수궤효응모형진행회췌분석，이수교육수평위초중급이하자위대조，기여조사대상지효협산적OR치급기95%CI분별위：고중/중전2.12（1.65，2.72）、대학급이상6.24（4.24，9.19）；조사대상복용협산적OR치급기95%CI분별위：고중/중전1.63（1.39，1.93）、대학급이상3.48（2.35，5.16），차이균유통계학의의。결론：아국육령부녀수교육수평여기대협산적인지급복용협산유관。응중점가강수교육수평교저적육령부녀대협산적인지화정학복용적상관교육，이진일보강저신생인신경관기형발생적개솔，제고아국모영건강수평。
Objective:To investigate the relationship between the educational level of Chinese child-bearing women and their knowledge on supplementation of folic acid, by the Meta-analysis of the published data. Methods:Searches were done by using Pubmed (up to Apr. 19th, 2014) with English, and Sinomed, CNKI and VIP with Chinese . The search term combined with the keywords as follows: "folic acid", "pregnancy"and "China" was used to search English papers, while the search term combined with the keywords as: "folic acid" and "women" was used to search Chinese papers. Studies involved in this meta-analysis were defined as the observational study, including the information about the association between the educational level of child-bearing women and their knowledge and/or supplementation of folic acid. Only Chinese women were involved in the studies. Results:A total of 436 papers including 339 Chinese papers and 97 English papers were collected. After selection according to the criterion, a total of 15 eligible studies were remained in the Meta-analysis. Random effect models were used. Meta-analysis showed that the OR values and the related 95%CIs of the knowledge on folic acid were: 2.12 (1.65, 2.72) in those women with high school/technical secondary school education, 6.24 (4.24, 9.19) in those women with at least college education, when compared with those women with less than junior middle school education; and that the OR values and the related 95%CIs of the folic acid supplementation were 1.63 (1.39, 1.93) and 3.48 (2.35, 5.16) in two groups when compared analogously. Conclusions:The knowledge and supplementation of folic acid is related to their educational level in those Chinese child-bearing women. To prevent neural tube defects and to improve the health situation of Chinese women and children, it is necessary to enhance the health education on folic acid for those women with relatively less education.