CAJ | 학술논문

目的：研究与分析免疫学检验联合检测应用于系统性红斑狼疮中的诊断价值。方法选取64例系统性红斑狼疮作为研究组，其中27例活动期患者为活动组，37例非活动期患者为非活动组，另外选取同期64例健康体检者作为对照组。对所有受检对象进行免疫学联合检测，然后将所检测结果进行比较与分析。结果经检测发现，活动组系统性红斑狼疮患者 IgG 和 IgA 及 IgM 指标均明显高于对照组（ P ﹤0.05）；而 C3和 C4水平均明显低于对照组（ P ﹤0.05）。非活动组系统性红斑狼疮患者 IgG 和 IgA 指标均明显高于对照组（ P ﹤0.05）；然其他各项免疫学检验指标与对照组比较（ P ﹥0.05）。经检测发现，抗核抗体谱（ANAS）和抗双链脱氧核糖核酸抗体（ds - DNA）抗体及可提取核抗原（ENA）检测中，研究组各项指标阳性率检出明显高于对照组（ P ﹤0.05），且对照组中各项指标检测均为阴性。结论临床上联合检测免疫学各项指标对诊断系统性红斑狼疮具有重要参考价值，同时可有效判断患者病情发展情况，可有效预示患者预后情况，并为临床诊断和治疗提供方向。
목적：연구여분석면역학검험연합검측응용우계통성홍반랑창중적진단개치。방법선취64례계통성홍반랑창작위연구조，기중27례활동기환자위활동조，37례비활동기환자위비활동조，령외선취동기64례건강체검자작위대조조。대소유수검대상진행면역학연합검측，연후장소검측결과진행비교여분석。결과경검측발현，활동조계통성홍반랑창환자 IgG 화 IgA 급 IgM 지표균명현고우대조조（ P ﹤0.05）；이 C3화 C4수평균명현저우대조조（ P ﹤0.05）。비활동조계통성홍반랑창환자 IgG 화 IgA 지표균명현고우대조조（ P ﹤0.05）；연기타각항면역학검험지표여대조조비교（ P ﹥0.05）。경검측발현，항핵항체보（ANAS）화항쌍련탈양핵당핵산항체（ds - DNA）항체급가제취핵항원（ENA）검측중，연구조각항지표양성솔검출명현고우대조조（ P ﹤0.05），차대조조중각항지표검측균위음성。결론림상상연합검측면역학각항지표대진단계통성홍반랑창구유중요삼고개치，동시가유효판단환자병정발전정황，가유효예시환자예후정황，병위림상진단화치료제공방향。
Objective To research and analyze immunological test joint detection in the diagnosis of systemic lupus erythematosus. Meth-ods We selected 64 cases of systemic lupus erythematosus patients as study group,who were divided into 27 patients with active group,37 pa-tients with non active to inactive group. At the same time,64 healthy volunteers were selected as control group. All subjects performed combined detection of immunology,then the test results were compared and analyzed. Results After testing found that,the IgG and IgA and IgM index in group activity in patients with systemic lupus erythematosus were significantly higher than those in control group( P ﹤ 0. 05). While the C3 and C4 levels were significantly lower than those in the control group( P ﹤ 0. 05). The IgG in systemic lupus erythematosus patients and IgA index in the inactive group were significantly higher than those in control group( P ﹤ 0. 05). After testing,this study found that the positive rate in study group were significantly higher than those in the control group including ANAS and anti ds - DNA antibody and ENA detection( P ﹤ 0. 05),the indexes in all the detection indexes were negative in healthy people. Conclusion Clinical immunology indexes of combined detection has impor-tant reference value for the diagnosis of systemic lupus erythematosus. These indexes can effectively judge the patients condition,and can effective-ly predict the prognosis of patients and provide direction for the clinical diagnosis and treatment.