临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015年
1期
41-43
,共3页
小儿%肺炎支原体肺炎%阿奇霉素%孟鲁司特钠%C 反应蛋白
小兒%肺炎支原體肺炎%阿奇黴素%孟魯司特鈉%C 反應蛋白
소인%폐염지원체폐염%아기매소%맹로사특납%C 반응단백
Children%Mycoplasma pneumoniae pneumonia%Azithromycin%Montelukast%CRP
目的：观察分析阿奇霉素联合孟鲁司特钠治疗小儿肺炎支原体肺炎的疗效及其对血清 C 反应蛋白（CRP）水平的影响。方法随机将85例肺炎支原体肺炎患儿随机分为观察组43例和对照组42例。对照组给予阿奇霉素序贯疗法，观察组给予阿奇霉素序贯疗法和孟鲁司特钠联合治疗。疗程结束后分析两组临床治疗效果、临床症状和体征（喘憋、湿啰音、咳嗽）消失时间、平均退热时间、平均住院时间、CRP 水平和药物安全性。结果治疗后观察组临床总有效率明显高于对照组（95.3％ vs.78.6％），差异具有显著性（ P ﹤0.05）。观察组临床症状和体征消失时间明显短于对照组，差异具有显著性（ P ﹤0.05）。且观察组平均退热时间和住院时间也明显短于对照组，差异具有显著性（ P ﹤0.05）。治疗治疗后两组 CRP 水平有明显降低，且观察组降低更明显，与对照组治疗后比较，差异具有显著性（ P ﹤0.05）。两组均未见严重不良反应。结论阿奇霉素和盂鲁司特钠联合使用治疗小儿支原体肺炎临床效果满意，能有效降低 CRP，快速缓解患儿临床症状和体征，安全性好，值得临床推广应用。
目的：觀察分析阿奇黴素聯閤孟魯司特鈉治療小兒肺炎支原體肺炎的療效及其對血清 C 反應蛋白（CRP）水平的影響。方法隨機將85例肺炎支原體肺炎患兒隨機分為觀察組43例和對照組42例。對照組給予阿奇黴素序貫療法，觀察組給予阿奇黴素序貫療法和孟魯司特鈉聯閤治療。療程結束後分析兩組臨床治療效果、臨床癥狀和體徵（喘憋、濕啰音、咳嗽）消失時間、平均退熱時間、平均住院時間、CRP 水平和藥物安全性。結果治療後觀察組臨床總有效率明顯高于對照組（95.3％ vs.78.6％），差異具有顯著性（ P ﹤0.05）。觀察組臨床癥狀和體徵消失時間明顯短于對照組，差異具有顯著性（ P ﹤0.05）。且觀察組平均退熱時間和住院時間也明顯短于對照組，差異具有顯著性（ P ﹤0.05）。治療治療後兩組 CRP 水平有明顯降低，且觀察組降低更明顯，與對照組治療後比較，差異具有顯著性（ P ﹤0.05）。兩組均未見嚴重不良反應。結論阿奇黴素和盂魯司特鈉聯閤使用治療小兒支原體肺炎臨床效果滿意，能有效降低 CRP，快速緩解患兒臨床癥狀和體徵，安全性好，值得臨床推廣應用。
목적：관찰분석아기매소연합맹로사특납치료소인폐염지원체폐염적료효급기대혈청 C 반응단백（CRP）수평적영향。방법수궤장85례폐염지원체폐염환인수궤분위관찰조43례화대조조42례。대조조급여아기매소서관요법，관찰조급여아기매소서관요법화맹로사특납연합치료。료정결속후분석량조림상치료효과、림상증상화체정（천별、습라음、해수）소실시간、평균퇴열시간、평균주원시간、CRP 수평화약물안전성。결과치료후관찰조림상총유효솔명현고우대조조（95.3％ vs.78.6％），차이구유현저성（ P ﹤0.05）。관찰조림상증상화체정소실시간명현단우대조조，차이구유현저성（ P ﹤0.05）。차관찰조평균퇴열시간화주원시간야명현단우대조조，차이구유현저성（ P ﹤0.05）。치료치료후량조 CRP 수평유명현강저，차관찰조강저경명현，여대조조치료후비교，차이구유현저성（ P ﹤0.05）。량조균미견엄중불량반응。결론아기매소화우로사특납연합사용치료소인지원체폐염림상효과만의，능유효강저 CRP，쾌속완해환인림상증상화체정，안전성호，치득림상추엄응용。
Objective To observe and analyse the effect of azithromycin combined with montelukast in therapy of mycoplasma pneumoniae pneumonia in children and reactive protein levels of serum C. Methods Eighty - five cases of mycoplasma pneumonia in children were randomly divided into observation group(42 cases)and control group(43 cases). The control group was given azithromycin sequential therapy,while the observation group was given azithromycin combined with montelukast. The clinical outcomes,clinical signs and symptoms(wheezing,crackles, cough)disappeared time,cooling time,the average length of hospital stay,CRP levels and drug safety were analyzed after the end of treatment in two groups. Resluts The total clinical efficiency in observation group after treatment was significantly higher than that of control group(95. 3%vs. 78. 6% )( P ﹤ 0. 05). The clinical symptoms and signs disappeared time and cooling time,the average hospital stay in observation group was significantly shorter than those of control group( P ﹤ 0. 05). Comparison of therapeutic effects after treatment,CRP levels were significantly re-duced in two groups,and the observation group significantly reduced( P ﹤ 0. 05). No serious adverse reactions were found in two groups. Con-clusion Azithromycin combined with montelukast have significant clinical effect on mycoplasma pneumoniae pneumonia in children,can effective-ly reduce CRP,relieve rapidly of clinical symptoms and signs. It was worthy of clinical application.
