临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2015年
1期
12-14
,共3页
妊娠高血压综合征%瘦素%胱抑素C%人绒毛膜促性腺激素
妊娠高血壓綜閤徵%瘦素%胱抑素C%人絨毛膜促性腺激素
임신고혈압종합정%수소%광억소C%인융모막촉성선격소
Pregnancy - induced hypertension%Leptin%Cystatin C%Human chorionic gonadotropin
目的：观察血清瘦素、胱抑素 C（CysC）和人绒毛膜促性腺激素（β- HCG）在妊娠高血压综合征检测中的意义。方法选取2011年1月至2014年6月收治的妊娠高血压患者150例为妊高症组；同期正常妊娠的患者60例为正常妊娠组；另选同期健康非妊娠妇女30例为健康对照组。观察健康对照组，正常妊娠组和妊高症组的瘦素、CysC 和β- HCG 水平，与妊高症严重程度的关系，各指标之间的相互关系。结果正常妊娠组和妊高症组的瘦素、CysC 和β-HCG 水平明显高于健康对照组（ P ﹤0.01），而妊高症组明显高于正常妊娠组（ P ﹤0.01）。随着妊高症病情严重程度的增加，瘦素，CysC 和β- HCG 水平出现明显的增高（ P ﹤0.01）。妊高症患者瘦素水平与 CysC（ r =0.673，P ﹤0.01）和β- HCG（ r =0.838，P ﹤0.01）水平呈正相关，CysC 与β- HCG（ r =0.792，P ﹤0.01）水平呈正相关。结论检测瘦素、CysC 和β- HCG 水平有助于对妊娠高血压患者的诊断和分级，其异常升高应引起临床的高度重视。
目的：觀察血清瘦素、胱抑素 C（CysC）和人絨毛膜促性腺激素（β- HCG）在妊娠高血壓綜閤徵檢測中的意義。方法選取2011年1月至2014年6月收治的妊娠高血壓患者150例為妊高癥組；同期正常妊娠的患者60例為正常妊娠組；另選同期健康非妊娠婦女30例為健康對照組。觀察健康對照組，正常妊娠組和妊高癥組的瘦素、CysC 和β- HCG 水平，與妊高癥嚴重程度的關繫，各指標之間的相互關繫。結果正常妊娠組和妊高癥組的瘦素、CysC 和β-HCG 水平明顯高于健康對照組（ P ﹤0.01），而妊高癥組明顯高于正常妊娠組（ P ﹤0.01）。隨著妊高癥病情嚴重程度的增加，瘦素，CysC 和β- HCG 水平齣現明顯的增高（ P ﹤0.01）。妊高癥患者瘦素水平與 CysC（ r =0.673，P ﹤0.01）和β- HCG（ r =0.838，P ﹤0.01）水平呈正相關，CysC 與β- HCG（ r =0.792，P ﹤0.01）水平呈正相關。結論檢測瘦素、CysC 和β- HCG 水平有助于對妊娠高血壓患者的診斷和分級，其異常升高應引起臨床的高度重視。
목적：관찰혈청수소、광억소 C（CysC）화인융모막촉성선격소（β- HCG）재임신고혈압종합정검측중적의의。방법선취2011년1월지2014년6월수치적임신고혈압환자150례위임고증조；동기정상임신적환자60례위정상임신조；령선동기건강비임신부녀30례위건강대조조。관찰건강대조조，정상임신조화임고증조적수소、CysC 화β- HCG 수평，여임고증엄중정도적관계，각지표지간적상호관계。결과정상임신조화임고증조적수소、CysC 화β-HCG 수평명현고우건강대조조（ P ﹤0.01），이임고증조명현고우정상임신조（ P ﹤0.01）。수착임고증병정엄중정도적증가，수소，CysC 화β- HCG 수평출현명현적증고（ P ﹤0.01）。임고증환자수소수평여 CysC（ r =0.673，P ﹤0.01）화β- HCG（ r =0.838，P ﹤0.01）수평정정상관，CysC 여β- HCG（ r =0.792，P ﹤0.01）수평정정상관。결론검측수소、CysC 화β- HCG 수평유조우대임신고혈압환자적진단화분급，기이상승고응인기림상적고도중시。
Objective To observe the clinical significance of serum leptin,cystatin C(CysC)and human chorionic gonadotropin(β -HCG)in patients with pregnancy - induced hypertension. Methods A total of 150 patients with pregnancy - induced hypertension during January 2011 to June 2014 were selected as pregnancy - induced hypertension group;60 patients with normal pregnancy at the same period were allocated in normal pregnancy group,and 30 healthy women without pregnancy were selected as healthy control group. Levels of leptin,CysC and β - HCG were examined among pregnancy - induced hypertension group,normal pregnancy group and healthy control group,the relationship among levels of leptin,CysC and β - HCG and the severity of patients with pregnancy - induced hypertension were observed,the correlation between each marker had been evaluated. Results Levels of leptin,CysC and β - HCG in women with normal pregnancy and patients with pregnancy - induced hyper-tension were significantly higher than those of control group( P ﹤ 0. 01),and their levels in pregnancy - induced hypertension group were signifi-cantly higher than those of normal pregnancy group( P ﹤ 0. 01). The levels of leptin,CysC and β - HCG were significantly elevated as the in-crease of severity of pregnancy - induced hypertension( P ﹤ 0. 01). The level of leptin in patients with pregnancy - induced hypertension was positively correlated with the levels of CysC( r = 0. 673,P ﹤ 0. 01)and β - HCG( r = 0. 838,P ﹤ 0. 01),there was also positive correlation between levels of CysC and β - HCG( r = 0. 792,P ﹤ 0. 01). Conclusion The detection of levels of leptin,CysC and β - HCG is helpful in diagnosis and classification of patients with pregnancy - induced hypertension,their abnormal elevation should lead physicians to pay more attention to these patients.
