CAJ | 학술논문

目的：探讨新疆维吾尔族（维族）胶质瘤中ATM及PTEN蛋白的表达与临床意义。方法运用免疫组化法检测50例新疆维族胶质瘤中ATM及PTEN蛋白的表达，同时以20例胶质瘤旁组织作为对照，分析其表达的差异及其表达与胶质瘤临床病理特征、患者生存期之间的关系。结果（1）新疆维族胶质瘤和胶质瘤旁组织中ATM蛋白表达的阳性率分别为60％（30／50）和10％（2／20）；PTEN蛋白表达的阳性率分别为30％（15／50）和75％（15／20）；（2）ATM及PTEN蛋白表达在胶质瘤和胶质瘤旁组织中的表达差异有统计学意义（均P＜0．001）；（3）ATM蛋白及PTEN蛋白在WHO分级、不同生存期各组中表达的差异均有统计学意义（均P＜0．05），在临床表现、性别、肿瘤大小、肿瘤部位、是否复发各组之间的差异均无统计学意义（均P＞0．05）。结论（1） ATM及PTEN蛋白在新疆维族胶质瘤中及胶质瘤旁组织中表达有差异，表明ATM及PTEN蛋白在胶质瘤发生发展中可能起到一定作用；（2）新疆维族胶质瘤中ATM及PTEN蛋白均与WHO分级和不同生存期表达相关，提示ATM及PTEN蛋白可作为判定胶质瘤生物学行为和预后判断的参考指标。
목적：탐토신강유오이족（유족）효질류중ATM급PTEN단백적표체여림상의의。방법운용면역조화법검측50례신강유족효질류중ATM급PTEN단백적표체，동시이20례효질류방조직작위대조，분석기표체적차이급기표체여효질류림상병리특정、환자생존기지간적관계。결과（1）신강유족효질류화효질류방조직중ATM단백표체적양성솔분별위60％（30／50）화10％（2／20）；PTEN단백표체적양성솔분별위30％（15／50）화75％（15／20）；（2）ATM급PTEN단백표체재효질류화효질류방조직중적표체차이유통계학의의（균P＜0．001）；（3）ATM단백급PTEN단백재WHO분급、불동생존기각조중표체적차이균유통계학의의（균P＜0．05），재림상표현、성별、종류대소、종류부위、시부복발각조지간적차이균무통계학의의（균P＞0．05）。결론（1） ATM급PTEN단백재신강유족효질류중급효질류방조직중표체유차이，표명ATM급PTEN단백재효질류발생발전중가능기도일정작용；（2）신강유족효질류중ATM급PTEN단백균여WHO분급화불동생존기표체상관，제시ATM급PTEN단백가작위판정효질류생물학행위화예후판단적삼고지표。
Objective To explore the expression and clinical significance of ATM and PTEN in gliomas of Uygur in Xinjiang .Method Immunohistochemistry was used to detect the expression of ATM and PTEN between 50 cases of gliomas and 20 cases of adjacent tissues .Results ( 1 ) The positive rate of ATM in gliomas and adjacent tissues respectively were 60%( 30/50 ) and 10%( 2/20).The positive rate of PTEN in gliomas and adjacent tissues respectively were 30%(15/50)and 75%( 15/20 ) .( 2 ) The difference of the expression of ATM and PTEN between gliomas and adjacent tissues was statistically significant (all P<0.001).(3)The differences of the expression of ATM and PTEN in different WHO histological grading and survival time groups were statistically significant (all P<0.05).The expression of ATM in different clinical performances , gender, tumor size, tumor position and recurrence or not groups had no statistical difference ( all P >0.05). Conclusions ( 1 ) The expression of ATM and PTEN in gliomas of Uygur in Xinjiang was differ from which in adjacent tissues may show that ATM and PTEN may play a certain role in the development and progression of gliomas of Uygur in Xinjiang .( 2 ) The expression of ATM and PTEN of Uygur in Xinjiang was related to WHO histological grading and survival time .They can be the judgers of the biological behavior ,prognosis factor of gliomas of Uygur in Xinjiang .