CAJ | 학술논문

目的：考察注射用盐酸氨溴索、更昔洛韦钠与8种溶媒配伍稳定性，并将二者配伍观察溶液稳定性，为临床合理用药提供参考。方法观察2种药物在0.9%氯化钠、5%葡萄糖、10%葡萄糖、复方氯化钠、葡萄糖氯化钠、木糖醇氯化钠、小儿电解质补给注射液和灭菌注射用水8种溶媒中以临床常用浓度溶解后0、0.5、1、2、4、6、8 h的pH值，观察2种溶液等体积混合和盐酸氨溴索以入壶给药加入到更昔洛韦钠的溶液中颜色、透明度的变化。结果8种溶媒和盐酸氨溴索溶液在8 h内pH值的RSD均在0~2.30%，更昔洛韦钠溶液的pH值的RSD在0~1.2%。2种药物等体积混合后均可见白色颗粒物。盐酸氨溴索入壶给药后立即产生白色沉淀。三组溶液在0~8 h的平均pH值分别进行检验，≤0.05，无显著性差异。结论三组溶液pH值在8 h内稳定，2种药物在8种溶媒中溶解后两两混合存在配伍禁忌，临床应用应注意。
목적：고찰주사용염산안추색、경석락위납여8충용매배오은정성，병장이자배오관찰용액은정성，위림상합리용약제공삼고。방법관찰2충약물재0.9%록화납、5%포도당、10%포도당、복방록화납、포도당록화납、목당순록화납、소인전해질보급주사액화멸균주사용수8충용매중이림상상용농도용해후0、0.5、1、2、4、6、8 h적pH치，관찰2충용액등체적혼합화염산안추색이입호급약가입도경석락위납적용액중안색、투명도적변화。결과8충용매화염산안추색용액재8 h내pH치적RSD균재0~2.30%，경석락위납용액적pH치적RSD재0~1.2%。2충약물등체적혼합후균가견백색과립물。염산안추색입호급약후립즉산생백색침정。삼조용액재0~8 h적평균pH치분별진행검험，≤0.05，무현저성차이。결론삼조용액pH치재8 h내은정，2충약물재8충용매중용해후량량혼합존재배오금기，림상응용응주의。
Objective To investigated the compatible stability of Ambroxol hydrochloride injection and Ganciclovir sodium injection in 8 solutions and to improve the rational use in the clinic. Methods The pH value of the compatible stability of the 2 injections in 8 solutions were determined within 0-8 h, respectively. The changes of color and transparency were observed after the 2 injections were mixed equal y at room temperature. Results The range of the relative standard deviation (RSD) of the pH value of the 8 solutions and the Ambroxol hydrochloride were between 0~2.3%in 8 h, respectively. The ganciclovir sodium was 0~1.2%. The white precipitate was observed when the ambroxol hydrochloride injection was mixed with ganciclovir sodium injection by the way of going into pot. The P value of the t test for the 3 groups were al less than 0.05. Conclusion The pH value of the 3 groups were al stable in 8 h. Ambroxol hydrochloride injection was shown to be incompatible with ganciclovir sodium injection in the 8 solutions.