CAJ | 학술논문

目的：探讨大剂量雾化人干扰素α1b 对治疗轮状病毒肠炎患儿的疗效。方法：收治轮状病毒肠炎患儿146例，按治疗方式分成对照组70例和治疗组76例。对照组实行常规治疗，治疗组在实行常规的治疗上，加用雾化吸入重组人干扰素α1b。吸入的剂量根据患儿的年龄和病情的轻重酌情而定，1次/d，连续治疗3 d；比较两组患者的治疗效果和止泻时间、退热时间。结果：治疗组的总有效率高于对照组，差异有统计学意义(P＜0.05)。治疗组的止泻时间和退热时间均短于对照组，差异有统计学意义(P＜0.05)。结论：大剂量雾化重组人干扰素α1b对治疗小儿轮状病毒肠炎的临床疗效有显著的提高。
목적：탐토대제량무화인간우소α1b 대치료륜상병독장염환인적료효。방법：수치륜상병독장염환인146례，안치료방식분성대조조70례화치료조76례。대조조실행상규치료，치료조재실행상규적치료상，가용무화흡입중조인간우소α1b。흡입적제량근거환인적년령화병정적경중작정이정，1차/d，련속치료3 d；비교량조환자적치료효과화지사시간、퇴열시간。결과：치료조적총유효솔고우대조조，차이유통계학의의(P＜0.05)。치료조적지사시간화퇴열시간균단우대조조，차이유통계학의의(P＜0.05)。결론：대제량무화중조인간우소α1b대치료소인륜상병독장염적림상료효유현저적제고。
Objective:To explore the curative effect of large dose of atomization of recombinant human interferonα1b in children with rotavirus enteritis.Methods:146 children with rotavirus enteritis were selected.According to the treatment,they were divided into the treatment group of 76 cases and the control group of 70 cases.The control group were given conventional treatment,while the treatment group were given atomization of recombinant human interferonα1b on the basis of conventional therapy.Inhalation dose was appropriate depending on the patients' age and the severity of illness,1 time/day,continuous treatment of 3 days.We compared the effect of treatment and the antidiarrheal time,cooling time of the two groups.Results:In the treatment group,the total efficiency was higher than that of the control group,and the difference had statistical significance(P<0.05).In the treatment group, antidiarrheal time and the cooling time were shorter than the control group,and the difference had statistical significance(P<0.05). Conclusion:The curative effect of large dose of atomization of recombinant human interferon α 1b in children with rotavirus enteritis was significant.