临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2015年
2期
42-43,45
,共3页
治疗药物监测%血药浓度%抗癫痫药%他克莫司%环孢素
治療藥物鑑測%血藥濃度%抗癲癇藥%他剋莫司%環孢素
치료약물감측%혈약농도%항전간약%타극막사%배포소
Therapeutic drug monitoring%Plasma concentration%Antiepileptic drugs%Tacrolimus%Cyclosporine
目的：对医院2012年1~12月7种治疗药物监测（TDM）的结果进行回顾性分析，探讨治疗药物监测在临床上的应用价值。方法应用均相酶放大免疫分析法（EMIT）测定他克莫司、环孢素、苯妥英钠、卡马西平、丙戊酸、苯巴必妥、万古霉素7种药物的血药浓度，并对测定结果进行分析总结。结果他克莫司和环孢素在肾移植术后抗排斥治疗中需要密切监测药物疗效和调整药物剂量。抗癫痫药的 TDM 未引起足够的重视，其中苯妥英钠出现中毒反应最多。万古霉素的临床送检量最少，与临床使用量少和血药浓度是否需要监测存在争议性有关。结论开展血药浓度监测，能减少药源性疾病的发生，提高癫痫患者的生活质量，保证患者用药安全有效。
目的：對醫院2012年1~12月7種治療藥物鑑測（TDM）的結果進行迴顧性分析，探討治療藥物鑑測在臨床上的應用價值。方法應用均相酶放大免疫分析法（EMIT）測定他剋莫司、環孢素、苯妥英鈉、卡馬西平、丙戊痠、苯巴必妥、萬古黴素7種藥物的血藥濃度，併對測定結果進行分析總結。結果他剋莫司和環孢素在腎移植術後抗排斥治療中需要密切鑑測藥物療效和調整藥物劑量。抗癲癇藥的 TDM 未引起足夠的重視，其中苯妥英鈉齣現中毒反應最多。萬古黴素的臨床送檢量最少，與臨床使用量少和血藥濃度是否需要鑑測存在爭議性有關。結論開展血藥濃度鑑測，能減少藥源性疾病的髮生，提高癲癇患者的生活質量，保證患者用藥安全有效。
목적：대의원2012년1~12월7충치료약물감측（TDM）적결과진행회고성분석，탐토치료약물감측재림상상적응용개치。방법응용균상매방대면역분석법（EMIT）측정타극막사、배포소、분타영납、잡마서평、병무산、분파필타、만고매소7충약물적혈약농도，병대측정결과진행분석총결。결과타극막사화배포소재신이식술후항배척치료중수요밀절감측약물료효화조정약물제량。항전간약적 TDM 미인기족구적중시，기중분타영납출현중독반응최다。만고매소적림상송검량최소，여림상사용량소화혈약농도시부수요감측존재쟁의성유관。결론개전혈약농도감측，능감소약원성질병적발생，제고전간환자적생활질량，보증환자용약안전유효。
Objective From January to December 2012,7 kinds of results of therapeutic drug monitoring(TDM) were retrospectively analyzed in our hospital to explore the value of therapeutic drug monitoring in clinical practice. Methods By using homogeneous enzyme immunoassay amplification(EMIT),the blood concentration of 7 kinds of drugs including ta-crolimus,cyclosporine,phenytoin,carbamazepine,valproic acid,benzene barbital,vancomycin were detected respectively. The measurement results were analyzed and summarized. Results The tacrolimus and cyclosporine in renal transplant recipients anti-rejection therapy demanded to be close monitoring and adjustment of the dose of drug efficacy. The TDM of antiepileptic drugs did not attract enough attention,including phenytoin appeared up to toxic reactions at most. The clinical inspection of vancomycin was minimum amount,this seemed to be connected with clinical use less and whether the blood concentration need to monitor was controversial. Conclusion The development of blood drug concentration monitoring can reduce the occurrence of drug induced diseases,improve the quality of life in patients with epilepsy and ensure the safety of patients effectively.
