CAJ | 학술논문

目的：观察硝苯地平联合硫酸镁治疗妊娠期高血压疾病的临床效果。方法选择2013年1月＿2014年1月收治的妊娠高血压患者212例，随机分为观察组和对照组各106例。对照组予25％硫酸镁20ml 加入5％葡萄糖溶液10ml 静脉注射，后予50ml 硫酸镁入5％葡萄糖溶液450ml 静脉滴注；观察组在对照组基础上予硝苯地平缓释片10mg 口服，3次/ d。比较2组患者收缩压（SBP）、舒张压（DBP）、24h 尿蛋白定量（24hUTP）、血液黏度、新生儿Apger 评分。结果观察组总有效率为84.9％明显高于对照组63.2％，差异有统计学意义（P ＜0.05）。与治疗前比较，2组治疗后血压、24h 尿蛋白定量、血液黏度均有改善（P ＜0.05），且观察组改善较为明显（P ＜0.05）。观察组新生儿 Apger 评分为（9.2±1.3）分，对照组为（9.1±1.6）分，2组比较差异无统计学意义（P ﹥0.05）。结论硝苯地平联合硫酸镁治疗妊娠期高血压疾病可较好的降低患者血压，且不良反应少，对胎儿影响小，安全性好，值得临床推广应用。
목적：관찰초분지평연합류산미치료임신기고혈압질병적림상효과。방법선택2013년1월＿2014년1월수치적임신고혈압환자212례，수궤분위관찰조화대조조각106례。대조조여25％류산미20ml 가입5％포도당용액10ml 정맥주사，후여50ml 류산미입5％포도당용액450ml 정맥적주；관찰조재대조조기출상여초분지평완석편10mg 구복，3차/ d。비교2조환자수축압（SBP）、서장압（DBP）、24h 뇨단백정량（24hUTP）、혈액점도、신생인Apger 평분。결과관찰조총유효솔위84.9％명현고우대조조63.2％，차이유통계학의의（P ＜0.05）。여치료전비교，2조치료후혈압、24h 뇨단백정량、혈액점도균유개선（P ＜0.05），차관찰조개선교위명현（P ＜0.05）。관찰조신생인 Apger 평분위（9.2±1.3）분，대조조위（9.1±1.6）분，2조비교차이무통계학의의（P ﹥0.05）。결론초분지평연합류산미치료임신기고혈압질병가교호적강저환자혈압，차불량반응소，대태인영향소，안전성호，치득림상추엄응용。
Objective To investigate the clinical effect of nifedipine combined with magnesium sulfate in the treat-ment of gestational hypertension. Methods 212 cases of patients with gestational hypertension from January 2013 to January 2014 was randomly divided into observation group(n = 106)and control group(n = 106). The control group was given 25%magnesium sulfate 20ml in 5% glucose solution 10ml,after 50ml magnesium sulfate in 5% glucose solution 450ml for intrave-nous infusion. The observation group was given extended release nifedipine tablets oral 10mg,3 time/ d. The systolic blood pres-sure(SBP),diastolic blood pressure(DBP),24h urinary protein(24hUTP),blood viscosity,Apger score of neonates of 2 groups were compared. Results The total effective rate was 84. 9% in observation group,which was higher than 63. 2% of the control group,the difference was statistically significant(P < 0. 05). Compared with before treatment,the blood pressure,24h urinary protein,blood viscosity of both groups improved after treatment(P < 0. 05),and the observation group improved obvi-ously compared with the control group(P < 0. 05). The neonatal Apger score of observation group was(9. 2 ± 1. 3)points,and the control group was(9. 1 ± 1. 6)points,the difference between the 2 groups had no statistical significance(P ﹥ 0. 05). Con-clusion Nifedipine combined with magnesium sulfate can be better to reduce the blood pressure of patients,with less adverse reaction,little impact on the fetus,and the security is good,which is worthy of clinical application.