临床合理用药杂志
臨床閤理用藥雜誌
림상합리용약잡지
CHINESE JOURNAL OF CLINICAL RATIONAL DRUG USE
2015年
2期
9-10
,共2页
慢性阻塞性肺疾病%急性加重期%布地奈德%氨溴索%雾化吸入
慢性阻塞性肺疾病%急性加重期%佈地奈德%氨溴索%霧化吸入
만성조새성폐질병%급성가중기%포지내덕%안추색%무화흡입
Chronic obstructive pulmonary disease%Acute exacerbation%Budesonide%Ambroxol%Aerosol inhalation
目的：探讨布地奈德混悬液联合氨溴索雾化吸入治疗慢性阻塞性肺疾病（COPD）急性加重期患者的临床疗效。方法选择急性加重期的 COPD 患者80例，分为观察组和对照组各40例。对照组给予持续低流量吸氧、抗感染、平喘、止咳化痰及维持水电解质酸碱平衡等常规治疗。观察组在常规治疗的基础上，给予布地奈德混悬液联合氨溴索雾化吸入。观察比较2组各项临床疗效指标。结果观察组呼吸困难程度总有效率为97.5％高于对照组的80.0％，差异有统计学意义（P ＜0.05）。观察组肺部啰音总有效率为95.0％高于对照组的75.0％，差异有统计学意义（P ＜0.05）。观察组无明显不良反应发生。结论布地奈德联合氨溴索雾化吸入治疗 COPD 急性加重期疗效好，无明显不良反应，值得临床推广。
目的：探討佈地奈德混懸液聯閤氨溴索霧化吸入治療慢性阻塞性肺疾病（COPD）急性加重期患者的臨床療效。方法選擇急性加重期的 COPD 患者80例，分為觀察組和對照組各40例。對照組給予持續低流量吸氧、抗感染、平喘、止咳化痰及維持水電解質痠堿平衡等常規治療。觀察組在常規治療的基礎上，給予佈地奈德混懸液聯閤氨溴索霧化吸入。觀察比較2組各項臨床療效指標。結果觀察組呼吸睏難程度總有效率為97.5％高于對照組的80.0％，差異有統計學意義（P ＜0.05）。觀察組肺部啰音總有效率為95.0％高于對照組的75.0％，差異有統計學意義（P ＜0.05）。觀察組無明顯不良反應髮生。結論佈地奈德聯閤氨溴索霧化吸入治療 COPD 急性加重期療效好，無明顯不良反應，值得臨床推廣。
목적：탐토포지내덕혼현액연합안추색무화흡입치료만성조새성폐질병（COPD）급성가중기환자적림상료효。방법선택급성가중기적 COPD 환자80례，분위관찰조화대조조각40례。대조조급여지속저류량흡양、항감염、평천、지해화담급유지수전해질산감평형등상규치료。관찰조재상규치료적기출상，급여포지내덕혼현액연합안추색무화흡입。관찰비교2조각항림상료효지표。결과관찰조호흡곤난정도총유효솔위97.5％고우대조조적80.0％，차이유통계학의의（P ＜0.05）。관찰조폐부라음총유효솔위95.0％고우대조조적75.0％，차이유통계학의의（P ＜0.05）。관찰조무명현불량반응발생。결론포지내덕연합안추색무화흡입치료 COPD 급성가중기료효호，무명현불량반응，치득림상추엄。
Objective To investigate the efficacy of nebulized budesonide combined with ambroxol atomization inhala-tion in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease(COPD). Methods 80 ca-ses of patients with acute exacerbations of COPD were divided into the observation group and control group,each of 40 cases. The control group was given continuous low flow oxygen,anti infection,bronchodilators,cough suppressant and expectorant, maintaining water electrolyte and acid-base balance and other conventional treatment. The observation group was given nebuliz-ed budesonide and ambroxol atomization inhalation on the basis of the conventional therapy. The clinical variable of 2 groups were observed and compared. Results The total effective rate of expiratory dyspnea in the observation group was 97. 5% , which was higher than 80. 0% of the control group,the difference was statistically significant(P<0. 05). The total effective rate of pulmonary rales in the observation group was 95. 0% ,which was higher than 75. 0% of the control group,the difference was statistically significant(P<0. 05). The observation group had no obvious adverse reaction. Conclusion The nebulized budesonide and ambroxol atomization inhalation have a positive curative effect in the treatment of acute exacerbation of COPD, with no obvious adverse reaction,which is worthy of clinical promotion.
