中国继续医学教育
中國繼續醫學教育
중국계속의학교육
CHINA CONTINUING MEDICAL EDUCATION
2015年
2期
31-33
,共3页
光动力疗法%雷珠单抗%特发性脉络膜新生血管
光動力療法%雷珠單抗%特髮性脈絡膜新生血管
광동력요법%뢰주단항%특발성맥락막신생혈관
Photodynamic therapy%Ranibizumab%Idiopathic choroidal nevasularization
目的：评价光动力疗法（photodynamic therapy, PDT）联合玻璃体腔注射雷珠单抗治疗特发性脉络膜新生血管(idiopathic choroidal neovascularization，简称特发性CNV)的临床疗效。方法临床确诊为活动期特发性CNV患者30例30眼，随机分为PDT治疗组（PDT组）及PDT联合玻璃体腔注射雷珠单抗治疗组（联合组）。对比分析治疗前及治疗后1,3mo患者最佳矫正视力（best corrected visual acuity, BCVA）及黄斑中心厚度（central macular thickness, CMT）变化。结果治疗后1mo，3 mo分别与治疗前相比：PDT组及联合组BCVA平均值均提高，CMT平均值均降低，差异具有统计学意义（P＜0.05）；两组间比较BCVA变化及CMT变化差异具有统计学意义（P＜0.05）。治疗后3mo与1mo相比：PDT组与联合治疗组BCVA平均值、CMT平均值差异均无统计学意义（P＞0.05）。结论 PDT治疗与PDT联合玻璃体腔注射雷珠单抗治疗均可减少CNV引起的视力下降；联合治疗的效果及稳定性要优于单纯的PDT治疗。
目的：評價光動力療法（photodynamic therapy, PDT）聯閤玻璃體腔註射雷珠單抗治療特髮性脈絡膜新生血管(idiopathic choroidal neovascularization，簡稱特髮性CNV)的臨床療效。方法臨床確診為活動期特髮性CNV患者30例30眼，隨機分為PDT治療組（PDT組）及PDT聯閤玻璃體腔註射雷珠單抗治療組（聯閤組）。對比分析治療前及治療後1,3mo患者最佳矯正視力（best corrected visual acuity, BCVA）及黃斑中心厚度（central macular thickness, CMT）變化。結果治療後1mo，3 mo分彆與治療前相比：PDT組及聯閤組BCVA平均值均提高，CMT平均值均降低，差異具有統計學意義（P＜0.05）；兩組間比較BCVA變化及CMT變化差異具有統計學意義（P＜0.05）。治療後3mo與1mo相比：PDT組與聯閤治療組BCVA平均值、CMT平均值差異均無統計學意義（P＞0.05）。結論 PDT治療與PDT聯閤玻璃體腔註射雷珠單抗治療均可減少CNV引起的視力下降；聯閤治療的效果及穩定性要優于單純的PDT治療。
목적：평개광동력요법（photodynamic therapy, PDT）연합파리체강주사뢰주단항치료특발성맥락막신생혈관(idiopathic choroidal neovascularization，간칭특발성CNV)적림상료효。방법림상학진위활동기특발성CNV환자30례30안，수궤분위PDT치료조（PDT조）급PDT연합파리체강주사뢰주단항치료조（연합조）。대비분석치료전급치료후1,3mo환자최가교정시력（best corrected visual acuity, BCVA）급황반중심후도（central macular thickness, CMT）변화。결과치료후1mo，3 mo분별여치료전상비：PDT조급연합조BCVA평균치균제고，CMT평균치균강저，차이구유통계학의의（P＜0.05）；량조간비교BCVA변화급CMT변화차이구유통계학의의（P＜0.05）。치료후3mo여1mo상비：PDT조여연합치료조BCVA평균치、CMT평균치차이균무통계학의의（P＞0.05）。결론 PDT치료여PDT연합파리체강주사뢰주단항치료균가감소CNV인기적시력하강；연합치료적효과급은정성요우우단순적PDT치료。
Objective To investigate the efifcacy of photodynamic therapy (PDT) and intravitreal injection with ranibizumab on idiopathic choroidal nevasularization (CNV). Methods There were patients (30 eyes) who were diagnosed as idiopathic CNV. Randomly separate them into PDT group and combination group. We analyzed the changes in best corrected visual acuity and central macular thickness before and 1,3mo after the treatment. Results One month and three month after the treatment in PDT group and combination group: the BCVA increased while the CMT decreased compared with that of pretreatment (P<0.05), changes of BCVA and CMT showed statistically significant between two groups (P<0.05). Compared 3mo with 1mo after treatment: there was no significant difference in the BCVA and CMT changes (P>0.05). Conclusion Not only PDT but also PDT combined with inravitreal injection of ranibizumab could reduce the danger of causing descent of vision. Effects and the stability of the combination therapy was superior to PDT treatment.
