中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2015年
2期
12-14
,共3页
达英%二甲双胍%胰岛素抵抗%多囊卵巢综合征
達英%二甲雙胍%胰島素牴抗%多囊卵巢綜閤徵
체영%이갑쌍고%이도소저항%다낭란소종합정
Diane%Metformin%Insulin resistance%Polycystic ovary syndrome
目的：探讨达英与二甲双胍联合对胰岛素抵抗合并多囊卵巢综合征(PCOS)患者的临床疗效，为临床提供参考。方法：选择笔者所在医院收治的84例PCOS患者，将所有患者随机分为A、B、C组，各28例。A、B、C组患者分别以二甲双胍、达英-35、二甲双胍联合达英-35服用。观察三组患者治疗前、治疗后的卵巢体积、卵泡刺激素(FSH)等指标。结果：A组治疗前后的卵巢体积、T、FINS、FPG及HOMA-IR比较，差异均有统计学意义(t=2.586、5.737、10.239、3.548、9.189，P<0.05)。B组治疗前后的卵巢体积、LH、T、FINS、FPG及HOMA-IR比较，差异均有统计学意义(t=2.564、4.921、19.411、10.532、2.842、12.558，P<0.05)。C组治疗前后的卵巢体积、LH、FSH、T、FINS、FPG及HOMA-IR比较，差异均有统计学意义(t=2.561、7.070、4.257、34.610、12.720、6.623、20.805，P<0.05)。三组患者的卵巢体积、LH、T、HOMA-IR指标比较，差异均有统计学意义(Z=6.281、7.328、6.820、6.829，P<0.05)。三组月经恢复率、排卵率及妊娠率比较差异均有统计学意义(字2=12.349、6.921、5.927， P<0.05)。结论：二甲双胍联合达英-35对于胰岛素抵抗合并多囊卵巢综合征疗效显著。
目的：探討達英與二甲雙胍聯閤對胰島素牴抗閤併多囊卵巢綜閤徵(PCOS)患者的臨床療效，為臨床提供參攷。方法：選擇筆者所在醫院收治的84例PCOS患者，將所有患者隨機分為A、B、C組，各28例。A、B、C組患者分彆以二甲雙胍、達英-35、二甲雙胍聯閤達英-35服用。觀察三組患者治療前、治療後的卵巢體積、卵泡刺激素(FSH)等指標。結果：A組治療前後的卵巢體積、T、FINS、FPG及HOMA-IR比較，差異均有統計學意義(t=2.586、5.737、10.239、3.548、9.189，P<0.05)。B組治療前後的卵巢體積、LH、T、FINS、FPG及HOMA-IR比較，差異均有統計學意義(t=2.564、4.921、19.411、10.532、2.842、12.558，P<0.05)。C組治療前後的卵巢體積、LH、FSH、T、FINS、FPG及HOMA-IR比較，差異均有統計學意義(t=2.561、7.070、4.257、34.610、12.720、6.623、20.805，P<0.05)。三組患者的卵巢體積、LH、T、HOMA-IR指標比較，差異均有統計學意義(Z=6.281、7.328、6.820、6.829，P<0.05)。三組月經恢複率、排卵率及妊娠率比較差異均有統計學意義(字2=12.349、6.921、5.927， P<0.05)。結論：二甲雙胍聯閤達英-35對于胰島素牴抗閤併多囊卵巢綜閤徵療效顯著。
목적：탐토체영여이갑쌍고연합대이도소저항합병다낭란소종합정(PCOS)환자적림상료효，위림상제공삼고。방법：선택필자소재의원수치적84례PCOS환자，장소유환자수궤분위A、B、C조，각28례。A、B、C조환자분별이이갑쌍고、체영-35、이갑쌍고연합체영-35복용。관찰삼조환자치료전、치료후적란소체적、란포자격소(FSH)등지표。결과：A조치료전후적란소체적、T、FINS、FPG급HOMA-IR비교，차이균유통계학의의(t=2.586、5.737、10.239、3.548、9.189，P<0.05)。B조치료전후적란소체적、LH、T、FINS、FPG급HOMA-IR비교，차이균유통계학의의(t=2.564、4.921、19.411、10.532、2.842、12.558，P<0.05)。C조치료전후적란소체적、LH、FSH、T、FINS、FPG급HOMA-IR비교，차이균유통계학의의(t=2.561、7.070、4.257、34.610、12.720、6.623、20.805，P<0.05)。삼조환자적란소체적、LH、T、HOMA-IR지표비교，차이균유통계학의의(Z=6.281、7.328、6.820、6.829，P<0.05)。삼조월경회복솔、배란솔급임신솔비교차이균유통계학의의(자2=12.349、6.921、5.927， P<0.05)。결론：이갑쌍고연합체영-35대우이도소저항합병다낭란소종합정료효현저。
Objective:To investigate the clinical efficacy of patients with polycystic ovary syndrome combined with insulin resistance treated with Diane and Metformin.Method:84 patients with polycystic ovary syndrome combined with insulin resistance were chosen in our hospital to receive treatment,they were divided into three groups,28 patients in each group.The group A,group B and group C were treated with Metformin,Diane-35,Diane-35 combined with Metformin.The ovarian volume,follicle stimulating hormone(FSH) and other indicators in three groups of patients before and after treatment were observed.Result:Before and after treatment,the ovarian volume,T,FINS,FPG and HOMA-IR of group A were compared,the differences were statistically significant(t=2.586,5.737,10.239,3.548,9.189,P<0.05).Before and after treatment,the ovarian volume,LH,T,FINS,FPG and HOMA-IR of group B were compared,the differences were statistically significant(t=2.564,4.921,19.411,10.532,2.842,12.558,P<0.05).Before and after treatment,the ovarian volume,LH,FSH,T,FINS,FPG and HOMA-IR of group C were compared,the differences was statistically significant(t=2.561,7.070,4.257,34.610, 12.720,6.623,20.805,P<0.05).The ovarian volume,LH,T,HOMA-IR index of three groups,the differences were statistically significant(Z=6.281,7.328,6.820,6.829,P<0.05).There were statistical differences in the recovery rate of menstruation,ovulation rate and pregnancy rate among the three groups(χ2=12.349, 6.921,5.927,P<0.05).Conclusion:The efficacy of insulin resistance in polycystic ovary syndrome treated with Diane-35 combined with Metformin is significant.
