CAJ | 학술논문

IGFBPs（ Insulin－like growth factor－binding proteins，胰岛素样生长因子结合蛋白）在进化上是高度保守的，在IGF（ Insulin－like growth factor，胰岛素样生长因子）系统中共有6种形式的IGFBPs，分别为IG－FBP－1～IGFBP－6，它们与配体IGFs具有高度的亲和性，能够调节IGFs与IGF－R（Insulin－like growth factor receptor，胰岛素样生长因子受体）的结合，这为IGF信号通路的调节提供了灵活的方式。其中，IGFBP－1是IGF结合蛋白家族中第一个被发现和鉴定的成员，一些分解代谢胁迫条件会诱导IGFBP－1 mRNA的高量表达。近年来体内的研究表明IGFBP－1被喻为是限制IGF信号系统功能的“分子开关”。在胁迫条件出现时，IGFBP－1通过限制能量的使用，将生命过程由高耗能的生长发育状态切换到仅能满足生物体生存的基本的低耗能状态。本文就近年来在哺乳类和鱼类模型中IGFBP－1调控的分子机制以及生物学功能的研究进展作一综述。
IGFBPs（ Insulin－like growth factor－binding proteins，이도소양생장인자결합단백）재진화상시고도보수적，재IGF（ Insulin－like growth factor，이도소양생장인자）계통중공유6충형식적IGFBPs，분별위IG－FBP－1～IGFBP－6，타문여배체IGFs구유고도적친화성，능구조절IGFs여IGF－R（Insulin－like growth factor receptor，이도소양생장인자수체）적결합，저위IGF신호통로적조절제공료령활적방식。기중，IGFBP－1시IGF결합단백가족중제일개피발현화감정적성원，일사분해대사협박조건회유도IGFBP－1 mRNA적고량표체。근년래체내적연구표명IGFBP－1피유위시한제IGF신호계통공능적“분자개관”。재협박조건출현시，IGFBP－1통과한제능량적사용，장생명과정유고모능적생장발육상태절환도부능만족생물체생존적기본적저모능상태。본문취근년래재포유류화어류모형중IGFBP－1조공적분자궤제이급생물학공능적연구진전작일종술。
The insulin -like growth factor -binding proteins ( IGFBPs ) are evolutionarily conserved components of the insulin-like growth factor ( IGF) system.There are six forms of IGFBPs, IGFBP-1~IG-FBP-6 .They have high affinity with IGFs and can regulate the combination of IGFs with their receptors, which provide additional flexibilities in regulating IGF signaling.IGFBP-1, the first identified member of the IGFBP family, is highly inducible under a variety of catabolic conditions.Recent in vivo studies have indica-ted that the IGFBP-1 serves as a molecular switch restricting IGF signaling and diverts the limited energy re-sources from growth and development towards metabolic processes essential for survival under stress condi-tions.This article reviewed the recent understandings of the molecular mechanism of IGFBP-1 regulation and its biological functions.