CAJ | 학술논문

目的：探讨S100A4和 HIF‐1α与卵巢浆液性囊腺癌预后的关系。方法：收集50例卵巢浆液性囊腺癌，28例卵巢浆液性囊腺瘤和15例正常卵巢组织为对照，采用免疫组织化学法检测S100A4和HIF‐1α的表达，并分析与患者预后的关系。结果：S100A4和HIF‐1α在卵巢浆液性囊腺癌组织中高表达，而在卵巢浆液性囊腺瘤组和正常卵巢组中低表达或不表达。S100A4与HIF‐1α表达呈显著正相关性。S100A4与铂化疗耐药无统计学意义（P＞0．05），HIF‐1α与铂化疗耐药有密切关系（P＜0．05）。S100A4和 HIF‐1α同时表达与铂化疗耐药密切相关（P＜0．05）；同时S100A4和HIF‐1α阳性表达患者的生存时间较阴性者明显减少（P＜0．05）。结论：S100A4和HIF‐1α的表达促进卵巢浆液性囊腺癌的发生发展，并且与患者铂化疗耐药和生存时间相关。
목적：탐토S100A4화 HIF‐1α여란소장액성낭선암예후적관계。방법：수집50례란소장액성낭선암，28례란소장액성낭선류화15례정상란소조직위대조，채용면역조직화학법검측S100A4화HIF‐1α적표체，병분석여환자예후적관계。결과：S100A4화HIF‐1α재란소장액성낭선암조직중고표체，이재란소장액성낭선류조화정상란소조중저표체혹불표체。S100A4여HIF‐1α표체정현저정상관성。S100A4여박화료내약무통계학의의（P＞0．05），HIF‐1α여박화료내약유밀절관계（P＜0．05）。S100A4화 HIF‐1α동시표체여박화료내약밀절상관（P＜0．05）；동시S100A4화HIF‐1α양성표체환자적생존시간교음성자명현감소（P＜0．05）。결론：S100A4화HIF‐1α적표체촉진란소장액성낭선암적발생발전，병차여환자박화료내약화생존시간상관。
Objective:To study the expression of S100A4 and HIF‐1αprotein in Ovarian Serous Cystadenocarcinoma , analyzed the relationship between the two proteins .Methods:Immunohistochemistry method was used to detect S100A4 and HIF‐1αproteins expression and analysis the correlation of proteins expression in Ovarian Serous Cystadenocarcino‐ma .Results:S100A4 and HIF‐1αin Ovarian Serous Cystadenocarcinoma showed a high expression .S100A4 protein ex‐pression in Ovarian Serous carcinoma was positive relation with HIF‐1αprotein expression .The expression of S100A4 and HIF‐1αprotein existed intimate relation with cisplatin‐based chemotherapy resistance (P<0 .05) .They are associ‐ated with overall survival ,longer the overall survival ,lower the expression (P< 0 .05) .Conclusion:Expression of S100A4 and HIF‐1α existed significant positive correlation .High S100A4 and HIF‐1α expression predicts cisplatin‐based chemotherapy resistance and the overall survival in Ovarian Serous Cystadenocarcinoma .