医学理论与实践
醫學理論與實踐
의학이론여실천
The Journal of Medical Theory and Practice
2015年
1期
3-5,10
,共4页
李文学%孔德荣%张丽霞%李猛%殷晓%赵青霞%马闯胜%赵中健%霍军%奈效祯
李文學%孔德榮%張麗霞%李猛%慇曉%趙青霞%馬闖勝%趙中健%霍軍%奈效禎
리문학%공덕영%장려하%리맹%은효%조청하%마틈성%조중건%곽군%내효정
阿立哌唑%齐拉西酮%利培酮%雌二醇%睾酮
阿立哌唑%齊拉西酮%利培酮%雌二醇%睪酮
아립고서%제랍서동%리배동%자이순%고동
Aripiprazone%Ziprasidone%Risperidone%Estradiol%Testosterone
目的：探讨女性精神分裂症患者用抗精神病药物治疗后雌二醇及睾酮水平变化。方法：收集本院2012年7月－2013年9月首发确诊女性精神分裂症患者180例作为研究组，将其随机分为阿立哌唑组、齐拉西酮组、利培酮组，每组60例，另选我院健康职工30例作为对照组。治疗前及治疗后1、3、6个月分别检测雌二醇及睾酮水平。结果：研究组雌二醇水平治疗前均明显低于对照组（P＜0．05）；利培酮组在治疗1、3、6个月雌二醇水平逐渐下降，且明显低于对照组（均 P＜0．05）；阿立哌唑组和齐拉西酮组在治疗1、3、6个月雌二醇水平逐渐升高，并逐渐接近于对照组（均 P＞0．05）。研究组睾酮治疗前均明显高于对照组（均 P＜0．05）；利培酮组在治疗1、3、6个月睾酮水平逐渐上升，且明显高于对照组（均 P＜0．05）；阿立哌唑组和齐拉西酮组在治疗1、3、6个月睾酮水平逐渐下降，并逐渐接近于对照组（均 P＞0．05）。结论：利培酮用药的患者容易出现雌二醇降低、睾酮升高等现象，而阿立哌唑及齐拉西酮却可以使雌二醇升高、睾酮降低。
目的：探討女性精神分裂癥患者用抗精神病藥物治療後雌二醇及睪酮水平變化。方法：收集本院2012年7月－2013年9月首髮確診女性精神分裂癥患者180例作為研究組，將其隨機分為阿立哌唑組、齊拉西酮組、利培酮組，每組60例，另選我院健康職工30例作為對照組。治療前及治療後1、3、6箇月分彆檢測雌二醇及睪酮水平。結果：研究組雌二醇水平治療前均明顯低于對照組（P＜0．05）；利培酮組在治療1、3、6箇月雌二醇水平逐漸下降，且明顯低于對照組（均 P＜0．05）；阿立哌唑組和齊拉西酮組在治療1、3、6箇月雌二醇水平逐漸升高，併逐漸接近于對照組（均 P＞0．05）。研究組睪酮治療前均明顯高于對照組（均 P＜0．05）；利培酮組在治療1、3、6箇月睪酮水平逐漸上升，且明顯高于對照組（均 P＜0．05）；阿立哌唑組和齊拉西酮組在治療1、3、6箇月睪酮水平逐漸下降，併逐漸接近于對照組（均 P＞0．05）。結論：利培酮用藥的患者容易齣現雌二醇降低、睪酮升高等現象，而阿立哌唑及齊拉西酮卻可以使雌二醇升高、睪酮降低。
목적：탐토녀성정신분렬증환자용항정신병약물치료후자이순급고동수평변화。방법：수집본원2012년7월－2013년9월수발학진녀성정신분렬증환자180례작위연구조，장기수궤분위아립고서조、제랍서동조、리배동조，매조60례，령선아원건강직공30례작위대조조。치료전급치료후1、3、6개월분별검측자이순급고동수평。결과：연구조자이순수평치료전균명현저우대조조（P＜0．05）；리배동조재치료1、3、6개월자이순수평축점하강，차명현저우대조조（균 P＜0．05）；아립고서조화제랍서동조재치료1、3、6개월자이순수평축점승고，병축점접근우대조조（균 P＞0．05）。연구조고동치료전균명현고우대조조（균 P＜0．05）；리배동조재치료1、3、6개월고동수평축점상승，차명현고우대조조（균 P＜0．05）；아립고서조화제랍서동조재치료1、3、6개월고동수평축점하강，병축점접근우대조조（균 P＞0．05）。결론：리배동용약적환자용역출현자이순강저、고동승고등현상，이아립고서급제랍서동각가이사자이순승고、고동강저。
Objective:To evaluate the effects of Aripiprazone Ziprasidone Risperidone‐ole on estradiol level and testos‐terone level of female schizophrenia patients. Methods:180 schizophrenia patients(study group) who had not been trea‐ted with any psychotropics were included and treated with Risperidone Ziprasidone and Aripiprazole in our hospital since July 2012 to September 2013, 60 cases in each group. Choose our hospital healthy female workers in 30 cases as control group. Serum estradiol level and testosterone level were tested and measured before and 6 months after treat‐ment. Results:The estradiol level of study group were significantly lower than control group before treatment(P<0.05). The estradiol level decreased gradually after treatment with risperidone, and was significantly lower than control group (P<0. 05). The estradiol level gradually increased after treatment with Aripiprazole and Ziprasidone, and were gradually closer to control group (P>0. 05). The testosterone level of study group were significantly higher than con‐trol group before treatment(P< 0. 05). The testosterone level increased gradually after treatment with Risperidone, and was significantly higher than control group (P<0. 05). The testosterone level gradually decreased after treatment with Aripiprazole and Ziprasidone, and were gradually closer to control group (P > 0. 05).Conclusion:The estradiol level decreased significantly, and the testosterone level elevated easily after treatment with risperidone. Aripiprazole and Ziprasidone could make lower testosterone, and higher estradiol. Ziprasidone and Aripiprazol are safedrugs in the treat‐ment of schizophrenia.
