检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2015年
1期
31-35
,共5页
张国英%钮晓红%徐卫平%夏厦
張國英%鈕曉紅%徐衛平%夏廈
장국영%뉴효홍%서위평%하하
CD4 +CD25highFoxP3 +调节性T淋巴细胞%干扰素γ%白细胞介素10%淋巴结核
CD4 +CD25highFoxP3 +調節性T淋巴細胞%榦擾素γ%白細胞介素10%淋巴結覈
CD4 +CD25highFoxP3 +조절성T림파세포%간우소γ%백세포개소10%림파결핵
CD4+CD25 high FoxP3 +regulatory T lymphocyte%Interferon gamma%Interleukin 10%Lymph tuberculosis
目的:研究淋巴结核患者外周血CD4+CD25 high FoxP3+调节性T淋巴细胞(Treg)和干扰素γ(IFN-γ)、白细胞介素10(IL-10)水平的变化及临床意义。方法采用流式细胞仪对100例淋巴结核患者及30名正常人外周血CD4+CD25highFoxP3+Treg和IFN-γ、IL-10水平进行检测。结果淋巴结核患者组与正常对照组比较,外周血CD4+CD25highFoxP3+Treg和IL-10水平均升高(P<0.05),而IFN-γ水平则降低(P<0.05)。在干酪样型、增殖型和混合型3种类型的淋巴结核病之间各指标差异均无统计学意义(P>0.05)。结论淋巴结核患者细胞免疫功能明显异常。CD4+CD25highFoxP3+Treg和IFN-γ、IL-10在淋巴结核的发病过程中发挥了重要作用。
目的:研究淋巴結覈患者外週血CD4+CD25 high FoxP3+調節性T淋巴細胞(Treg)和榦擾素γ(IFN-γ)、白細胞介素10(IL-10)水平的變化及臨床意義。方法採用流式細胞儀對100例淋巴結覈患者及30名正常人外週血CD4+CD25highFoxP3+Treg和IFN-γ、IL-10水平進行檢測。結果淋巴結覈患者組與正常對照組比較,外週血CD4+CD25highFoxP3+Treg和IL-10水平均升高(P<0.05),而IFN-γ水平則降低(P<0.05)。在榦酪樣型、增殖型和混閤型3種類型的淋巴結覈病之間各指標差異均無統計學意義(P>0.05)。結論淋巴結覈患者細胞免疫功能明顯異常。CD4+CD25highFoxP3+Treg和IFN-γ、IL-10在淋巴結覈的髮病過程中髮揮瞭重要作用。
목적:연구림파결핵환자외주혈CD4+CD25 high FoxP3+조절성T림파세포(Treg)화간우소γ(IFN-γ)、백세포개소10(IL-10)수평적변화급림상의의。방법채용류식세포의대100례림파결핵환자급30명정상인외주혈CD4+CD25highFoxP3+Treg화IFN-γ、IL-10수평진행검측。결과림파결핵환자조여정상대조조비교,외주혈CD4+CD25highFoxP3+Treg화IL-10수평균승고(P<0.05),이IFN-γ수평칙강저(P<0.05)。재간락양형、증식형화혼합형3충류형적림파결핵병지간각지표차이균무통계학의의(P>0.05)。결론림파결핵환자세포면역공능명현이상。CD4+CD25highFoxP3+Treg화IFN-γ、IL-10재림파결핵적발병과정중발휘료중요작용。
Objective To study the changes of peripheral blood CD4 +CD25 high FoxP3 +regulatory T lymphocytes (Treg)and interferon gamma (IFN-γ),interleukin 10 (IL-10)levels of patients with lymph tuberculosis and their clinical significance.Methods The levels of peripheral blood CD4 +CD25 high FoxP3 +Treg,IFN- γand IL-10 of 100 lymph tuberculosis patients and 30 healthy subjects were determined by flow cytometry.Results Compared with the healthy controls,the levels of peripheral blood CD4 +CD25highFoxP3 +Treg and IL-10 levels in lymph tuberculosis group increased with statistical significance (P<0.05 ),while IFN-γlevel decreased (P<0.05 ).Among the caseous, proliferation and mixed types of lymph tuberculosis,there was no significant difference (P>0.05 ).Conclusions Cellular immune function is significantly abnormal in patients with lymph tuberculosis.CD4 +CD25 high FoxP3 +Treg, IFN-γand IL-10 play important roles in the onset process of lymph tuberculosis.