检验医学
檢驗醫學
검험의학
LABORATORY MEDICINE
2015年
1期
36-39
,共4页
吴静静%陆逸彬%黄齐杰%姚玉亭%顾文莉
吳靜靜%陸逸彬%黃齊傑%姚玉亭%顧文莉
오정정%륙일빈%황제걸%요옥정%고문리
淋巴细胞亚群%外周血%口腔黏膜病%复发性阿佛他溃疡%口腔扁平苔藓
淋巴細胞亞群%外週血%口腔黏膜病%複髮性阿彿他潰瘍%口腔扁平苔蘚
림파세포아군%외주혈%구강점막병%복발성아불타궤양%구강편평태선
Lymphocyte subset%Peripheral blood%Oral mucosa disease%Recurrent aphthous ulcer%Oral lichen planus
目的:观察2种常见的口腔黏膜病———复发性阿佛他溃疡(RAU)和口腔扁平苔藓(OLP)患者外周血淋巴细胞亚群分类的变化,探讨其免疫学发病机制。方法用流式细胞术分析105例RAU 患者、70例OLP患者和65名健康对照者的外周血淋巴细胞亚群(总 T淋巴细胞、CD4+T 淋巴细胞、CD8+T 淋巴细胞、CD4+/CD8+、NK细胞、B细胞),比较各指标的组间差异。结果与健康对照组相比,RAU组总T细胞和CD8+T细胞显著增加(P<0.05、P<0.01),CD4+T细胞、CD4+/CD8+比值和B细胞均显著减少(P<0.01、P<0.001、P<0.05);而OLP组与健康对照组相比,CD8+T细胞显著降低(P<0.05);RAU组的总T细胞和CD8+T细胞显著高于OLP组(P<0.01、P<0.001)),而CD4+T细胞、CD4+/CD8+比值和NK细胞均显著低于OLP组(P<0.01、P<0.001、P<0.05)。结论 RAU和OLP患者多出现外周血淋巴细胞亚群百分率异常,细胞免疫功能紊乱,但二者的免疫状态存在差异,因此针对性的免疫干预将成为一项极具潜力的治疗措施。
目的:觀察2種常見的口腔黏膜病———複髮性阿彿他潰瘍(RAU)和口腔扁平苔蘚(OLP)患者外週血淋巴細胞亞群分類的變化,探討其免疫學髮病機製。方法用流式細胞術分析105例RAU 患者、70例OLP患者和65名健康對照者的外週血淋巴細胞亞群(總 T淋巴細胞、CD4+T 淋巴細胞、CD8+T 淋巴細胞、CD4+/CD8+、NK細胞、B細胞),比較各指標的組間差異。結果與健康對照組相比,RAU組總T細胞和CD8+T細胞顯著增加(P<0.05、P<0.01),CD4+T細胞、CD4+/CD8+比值和B細胞均顯著減少(P<0.01、P<0.001、P<0.05);而OLP組與健康對照組相比,CD8+T細胞顯著降低(P<0.05);RAU組的總T細胞和CD8+T細胞顯著高于OLP組(P<0.01、P<0.001)),而CD4+T細胞、CD4+/CD8+比值和NK細胞均顯著低于OLP組(P<0.01、P<0.001、P<0.05)。結論 RAU和OLP患者多齣現外週血淋巴細胞亞群百分率異常,細胞免疫功能紊亂,但二者的免疫狀態存在差異,因此針對性的免疫榦預將成為一項極具潛力的治療措施。
목적:관찰2충상견적구강점막병———복발성아불타궤양(RAU)화구강편평태선(OLP)환자외주혈림파세포아군분류적변화,탐토기면역학발병궤제。방법용류식세포술분석105례RAU 환자、70례OLP환자화65명건강대조자적외주혈림파세포아군(총 T림파세포、CD4+T 림파세포、CD8+T 림파세포、CD4+/CD8+、NK세포、B세포),비교각지표적조간차이。결과여건강대조조상비,RAU조총T세포화CD8+T세포현저증가(P<0.05、P<0.01),CD4+T세포、CD4+/CD8+비치화B세포균현저감소(P<0.01、P<0.001、P<0.05);이OLP조여건강대조조상비,CD8+T세포현저강저(P<0.05);RAU조적총T세포화CD8+T세포현저고우OLP조(P<0.01、P<0.001)),이CD4+T세포、CD4+/CD8+비치화NK세포균현저저우OLP조(P<0.01、P<0.001、P<0.05)。결론 RAU화OLP환자다출현외주혈림파세포아군백분솔이상,세포면역공능문란,단이자적면역상태존재차이,인차침대성적면역간예장성위일항겁구잠력적치료조시。
Objective To observe the changes of lymphocyte subsets of peripheral blood in 2 common oral mucosa diseases,recurrent aphthous ulcer (RAU ) and oral lichen planus (OLP ),and to investigate their immunological pathogenesis.Methods By flow cytometry,the lymphocyte subsets (total T cells,CD4 + T cells,CD8 +T cells, CD4 +/CD8,NK cells and B cells)in the peripheral blood of patients with RAU (105 cases),OLP (70 cases)and healthy controls (65 cases).The difference was analyzed comparatively between the groups.Results Compared with healthy controls,total T cells and CD8 +T cells in RAU group increased (P<0.05,P<0.01),but CD4 +T cells, CD4 +/CD8 +and B cells decreased in RAU group (P<0.01,P<0.001,P<0.05).In addition,CD8 +T cells in OLP group were lower than those in control group (P<0.05).The total T cells and CD8 +T cells in RAU group were higher than those in OLP group (P<0.01,P<0.001),while CD4 +T cells,CD4 +/CD8 +and NK cells in RAU group were significantly lower (P<0.01,P<0.001,P<0.05).Conclusions Owing to the imbalanced lymphocyte subset percentages,the cellular immune function of patients with RAU or OLP is often found to be abnormal,but their immune states are not completely same.So,the application of selective immunologic intervention may be the promising therapeutic measure to those oral mucosa diseases.