药学实践杂志
藥學實踐雜誌
약학실천잡지
THE JOURNAL OF PHARMACEUTICAL PRACTICE
2015年
1期
9-12,16
,共5页
双级靶向%纳米载体%脑肿瘤%诊断%治疗
雙級靶嚮%納米載體%腦腫瘤%診斷%治療
쌍급파향%납미재체%뇌종류%진단%치료
dual-targeting%nano-carrier%brain tumor%diagnosis%therapy
血脑屏障的存在严重阻碍了脑肿瘤化疗药物向脑内递送。纳米粒、脂质体、胶束等纳米载体可显著增加药物的穿过血脑屏障转运的能力，采用单一或双功能基制备的双级靶向纳米载体还可进一步增加药物的脑内递送及在脑肿瘤病变部位的浓集，从而显著提高脑肿瘤的诊断和治疗效果。笔者主要介绍双级靶向纳米载体的设计思路、靶向功能基的最新研究进展，为相关研究提供参考。
血腦屏障的存在嚴重阻礙瞭腦腫瘤化療藥物嚮腦內遞送。納米粒、脂質體、膠束等納米載體可顯著增加藥物的穿過血腦屏障轉運的能力，採用單一或雙功能基製備的雙級靶嚮納米載體還可進一步增加藥物的腦內遞送及在腦腫瘤病變部位的濃集，從而顯著提高腦腫瘤的診斷和治療效果。筆者主要介紹雙級靶嚮納米載體的設計思路、靶嚮功能基的最新研究進展，為相關研究提供參攷。
혈뇌병장적존재엄중조애료뇌종류화료약물향뇌내체송。납미립、지질체、효속등납미재체가현저증가약물적천과혈뇌병장전운적능력，채용단일혹쌍공능기제비적쌍급파향납미재체환가진일보증가약물적뇌내체송급재뇌종류병변부위적농집，종이현저제고뇌종류적진단화치료효과。필자주요개소쌍급파향납미재체적설계사로、파향공능기적최신연구진전，위상관연구제공삼고。
The delivery of therapeutical agents for brain tumors′ treatment is enormously prevented by the presence of blood‐brain barrier .Nano‐carriers such as nano‐particles ,liposomes and micelles can significantly increase the transport of drugs across the blood‐brain barrier .The dual‐targeting nano‐carriers modified by one or two functional groups can further increase the brain delivery of drugs as well as their accumulation in brain tumors ,resulting in significant improvement in the diagnosis and therapy of brain tumors .This article mainly focused on the recent development of strategies and functional groups of dual‐targeting nano‐carriers ,providing a reference for relevant investigations .
