CAJ | 학술논문

目的：考察注射用硝普钠与5％葡萄糖注射液、0．9％氯化钠注射液配伍的稳定性，为临床合理用药提供依据。方法采用高效液相色谱法，测定注射用硝普钠分别与2种溶媒（5％葡萄糖注射液、氯化钠注射液）配伍26 h内的含量变化，按2010年版《中国药典》微粒检测法中的光阻法检查微粒，并考察其外观、紫外‐可见吸收光谱及p H值和渗透压。结果26 h内配伍液的外观、紫外‐可见吸收光谱、pH值、含量及不溶性微粒均无显著性变化。结论注射用硝普钠与5％葡萄糖注射液、0.9％氯化钠注射液配伍26 h内稳定。
목적：고찰주사용초보납여5％포도당주사액、0．9％록화납주사액배오적은정성，위림상합리용약제공의거。방법채용고효액상색보법，측정주사용초보납분별여2충용매（5％포도당주사액、록화납주사액）배오26 h내적함량변화，안2010년판《중국약전》미립검측법중적광조법검사미립，병고찰기외관、자외‐가견흡수광보급p H치화삼투압。결과26 h내배오액적외관、자외‐가견흡수광보、pH치、함량급불용성미립균무현저성변화。결론주사용초보납여5％포도당주사액、0.9％록화납주사액배오26 h내은정。
Objective To study the stability of sodium nitroprusside for injection in 5% glucose injection and 0 .9%sodium chloride injection ,and provide reference for clinical rational drug use .Methods The content of sodium nitroprusside for injection in different dissolvants(5% glueose ,sodium chloride injection) within 26 h was determined by HPLC .The change of micro particle was measured by light blockage method in accordance with China pharmacopeia(2010 edition) ,and the appearance and UV visible absorption spectroscopy and pH ,the osmotic pressure of the mixtures were observed as well .Results The changes in appearnace ,UV visible absorption spectroscopy ,pH value ,content and microparticle were not significant .Conclusion Sodium nitroprusside for injection were stable within 26 h after mixing with different dissolvants (5% glueose ,sodium chloride injection) .