CAJ | 학술논문

目的：优选复方川芎滴丸的最佳制备工艺。方法以药物与基质的配比、滴制温度、冷却液的温度为考察因素，采用正交试验设计，以滴丸的圆整度、丸重差异、溶散时限、外观质量的综合评分为评价指标，优选滴丸的成型工艺；以滴距、滴速为考察因素，优选最佳滴制工艺。结果滴丸制备的最佳条件为药物中间体与基质配比1：2，滴制温度80℃，冷却剂温度15～20℃，滴距5 cm ，滴速40 gtt／min。结论该制备工艺合理，简便，易于控制，适用于本制剂的制备。
목적：우선복방천궁적환적최가제비공예。방법이약물여기질적배비、적제온도、냉각액적온도위고찰인소，채용정교시험설계，이적환적원정도、환중차이、용산시한、외관질량적종합평분위평개지표，우선적환적성형공예；이적거、적속위고찰인소，우선최가적제공예。결과적환제비적최가조건위약물중간체여기질배비1：2，적제온도80℃，냉각제온도15～20℃，적거5 cm ，적속40 gtt／min。결론해제비공예합리，간편，역우공제，괄용우본제제적제비。
Objective To optimize the preparation technology of compound Chuanxiong dropping pills .Methods Ratio of intermediate material to matrix ,dripping temperature and condensate temperature were used as factors ,with spherical de‐gree ,pill weight variatcon ,dissolve time limit coefficient and appearance quality as indexes ,the forming technology of compound Chuanxiong dropping pill was optimized by orthogonal test .The dropping preparation technology was optimized using dropping distance ,dropping speed as factors .Results The optimal preparation conditions were as follows:ratio of intermediate material to matrix was 1:2 ,dropping temperature was 80 ℃ ,temperature of condensate was 15‐20 ℃ ,dropping distance was 5 cm , dropping speed was 40 drops/min .Conclusion The preparation technology was reasonable ,simple and easy to control for the preparation of compound Chuanxiong dropping pills .