CAJ | 학술논문

目的：系统评价西药常规合用通心络胶囊治疗冠心病心绞痛的疗效。方法运用计算机检索2000年至2011年中国期刊网全文数据库（CNKI）、万方数据库、维普数据库和 PubMed ，并结合手工文献检索相关杂志、会议论文和学位论文，收集国内外公开发表的西药常规治疗＋通心络胶囊治疗冠心病心绞痛的随机对照试验（RC T ）。由2名研究者独立选择试验、评价质量、提取数据，并交叉核对。使用RevMan 4．2．2软件进行分析。结果纳入西药常规＋通心络胶囊（治疗组）与西药常规（对照组）对照评价治疗冠心病心绞痛有效率的RC T 11项，其中9项评价了心电图异常的改善率，11项评价了心绞痛症状的改善率。心电图疗效评价，治疗组相对于对照组相对危险度（RR）值为1．40（95％ CI：1．28～1．54），P＜0．01；心绞痛症状疗效评价，治疗组相对于对照组 R R值为1．25（95％ C I：1．18～1．32），P＜0．01。治疗组仅个别病例有轻微胃肠不适。结论在西医常规治疗的基础上合用通心络胶囊，能有效提高临床疗效，用药安全。
목적：계통평개서약상규합용통심락효낭치료관심병심교통적료효。방법운용계산궤검색2000년지2011년중국기간망전문수거고（CNKI）、만방수거고、유보수거고화 PubMed ，병결합수공문헌검색상관잡지、회의논문화학위논문，수집국내외공개발표적서약상규치료＋통심락효낭치료관심병심교통적수궤대조시험（RC T ）。유2명연구자독립선택시험、평개질량、제취수거，병교차핵대。사용RevMan 4．2．2연건진행분석。결과납입서약상규＋통심락효낭（치료조）여서약상규（대조조）대조평개치료관심병심교통유효솔적RC T 11항，기중9항평개료심전도이상적개선솔，11항평개료심교통증상적개선솔。심전도료효평개，치료조상대우대조조상대위험도（RR）치위1．40（95％ CI：1．28～1．54），P＜0．01；심교통증상료효평개，치료조상대우대조조 R R치위1．25（95％ C I：1．18～1．32），P＜0．01。치료조부개별병례유경미위장불괄。결론재서의상규치료적기출상합용통심락효낭，능유효제고림상료효，용약안전。
Objective To assess the effectiveness of western routine treatments combined with Tongxinluo capsule for angina pectoris .Methods The randomized controlled trials(RCTs ) of western routine treatments combined with tongxinluo capsule for angina pectoris were collected through searching on computer from the following databases ,CNKI (2000 -2011 ) ,WanFang Data (2000 -2011) ,WeiPu Data(2000-2011) ,PubMed(2000-2011) and manual search relevant journals ,conference papers .Results A total of 11 studies were included and improvement rate of abnormal ECG were estimated in 9 studies and improvement rate of symptoms of angina were estimated in 11 studies .ECG clinical evaluation of the treatment group relative to the control group ,relative risk (RR) value was 1 .40 (95% CI:1 .28‐1 .54) ,P<0 .01 ,symptoms of angina clinical evaluation ,treatment group relative to the control group RR value of 1.25 (95% CI:1 .18‐1 .32) ,P<0 .01 .Only slight gastrointestinal discomfort were found in treatment group .Conclusion Tongxinluo capsule in combination on the basis of conventional western treatment could effectively improve the clinical efficacy and drug safety .