CAJ | 학술논문

目的：分析重症颅脑损伤患者使用质子泵抑制剂（PPIs）出现胃肠道感染、医院获得性肺炎（HAP）的发生率，探讨重症颅脑损伤患者如何正确使用PPIs。方法查阅2011—2012年入院的141例重症颅脑损伤患者的病历，按未使用PPIs （17例）、长时间使用PPIs（59例）与短时间使用PPIs（65例）分为3组，并对使用PPIs后相关感染风险因素进行分析。结果使用PPIs组中胃肠道感染、HAP发生率较高，特别是长时间（超过9 d）使用者。用不同多变量的logistic回归分析，经GCS评分校正后，长时间使用PPIs是一风险因素。结论长时间使用PPIs可能是重症颅脑损伤患者胃肠道感染及 HAP的风险因素之一。临床使用PPIs时，除考虑病情外，还应注意使用时间。
목적：분석중증로뇌손상환자사용질자빙억제제（PPIs）출현위장도감염、의원획득성폐염（HAP）적발생솔，탐토중증로뇌손상환자여하정학사용PPIs。방법사열2011—2012년입원적141례중증로뇌손상환자적병력，안미사용PPIs （17례）、장시간사용PPIs（59례）여단시간사용PPIs（65례）분위3조，병대사용PPIs후상관감염풍험인소진행분석。결과사용PPIs조중위장도감염、HAP발생솔교고，특별시장시간（초과9 d）사용자。용불동다변량적logistic회귀분석，경GCS평분교정후，장시간사용PPIs시일풍험인소。결론장시간사용PPIs가능시중증로뇌손상환자위장도감염급 HAP적풍험인소지일。림상사용PPIs시，제고필병정외，환응주의사용시간。
Objective To analyze the occurrence rate of gastrointestinal and pulmonary infection and hospital acquired pneumonia (HAP)in severe craniocerebral injuries in my hospital using proton pump inhibitors (PPIs) ,discuss the right way to use PPIs for severe craniocerebral injuries .Methods The case histories of 141 severe craniocerebral injuries in my hospital from 2011 to 2012 were looked up ,and divided into three groups as follows :the group that never used PPIs(17 cases) ,the group that used PPIs for a long time (59 cases) ,and the group that used PPIs for a short time (65 cases) ,and the risks of getting infected using PPIs were analyzed in those three groups above .Results The patients in PPIs group had a higher risk of gastrointestinal tract infection and HAP ,especially who were treated with PPIs more than 9 days .Adjusted by GCS score ,using PPIs for a long time was a risk factor in different multivariate logistic .Conclusion Using PPIs for a long time might be a risk factor of gastro‐intestinal tract infection and HAP .Therefore ,apart from considering the state of illness ,more attention should be paid to the u‐sing time w hen use PPIs .