临床药物治疗杂志
臨床藥物治療雜誌
림상약물치료잡지
CLINICAL MEDICATION JOURNAL
2014年
z1期
11-16
,共6页
肿瘤细胞%肿瘤微环境%肿瘤治疗%靶向治疗
腫瘤細胞%腫瘤微環境%腫瘤治療%靶嚮治療
종류세포%종류미배경%종류치료%파향치료
tumor cel%tumor microenvironment%cancer therapy%targeting therapy
肿瘤微环境是肿瘤细胞赖以生存和发展的物质基础，肿瘤微环境和肿瘤细胞是一个相互依存、相互促进的整体。肿瘤微环境具有低氧、低pH、高间质液压的生理特性，其中存在着多种基质细胞、调控因子和蛋白酶等物质，为肿瘤的发生、发展、侵袭、转移、抵抗药物治疗和免疫反应等提供必要的物质基础。因此靶向肿瘤微环境的治疗策略成为治疗肿瘤的新思路，利用肿瘤微环境中的靶点和生理特性，靶向药物和靶向制剂能够更好地聚集在肿瘤部位，呈现出更好的治疗效果。
腫瘤微環境是腫瘤細胞賴以生存和髮展的物質基礎，腫瘤微環境和腫瘤細胞是一箇相互依存、相互促進的整體。腫瘤微環境具有低氧、低pH、高間質液壓的生理特性，其中存在著多種基質細胞、調控因子和蛋白酶等物質，為腫瘤的髮生、髮展、侵襲、轉移、牴抗藥物治療和免疫反應等提供必要的物質基礎。因此靶嚮腫瘤微環境的治療策略成為治療腫瘤的新思路，利用腫瘤微環境中的靶點和生理特性，靶嚮藥物和靶嚮製劑能夠更好地聚集在腫瘤部位，呈現齣更好的治療效果。
종류미배경시종류세포뢰이생존화발전적물질기출，종류미배경화종류세포시일개상호의존、상호촉진적정체。종류미배경구유저양、저pH、고간질액압적생리특성，기중존재착다충기질세포、조공인자화단백매등물질，위종류적발생、발전、침습、전이、저항약물치료화면역반응등제공필요적물질기출。인차파향종류미배경적치료책략성위치료종류적신사로，이용종류미배경중적파점화생리특성，파향약물화파향제제능구경호지취집재종류부위，정현출경호적치료효과。
Tumor microenvironment is the basis for the tumor cels to survive and develop. It is clear that tumor cels are in close interaction with the extracelular matrix and with stromal cels in the tumor microenvironment. The tumor microenvironment has characteristics of low oxygen, low pH, high interstitial fluid pressure. The tumor microenvironment composed of immune cells, angiogenic vascular cels, lymphatic endothelial cels, cancer associated ifbroblastic cels and the complex molecular components. These components may promote tumor formation and metastasis mainly via angiogenesis induction, suppression of immune surveilance and immune response, and breeding tumor stem cels. Targeting therapy at tumor microenvironment has several characters, such as strong effect, low toxicity and broad anti-tumor spectrum. The tumor stroma can be modulated, or re-educated to allow better delivery of chemotherapeutic drugs or enhance the efifciency of therapy.
