中西医结合心血管病电子杂志
中西醫結閤心血管病電子雜誌
중서의결합심혈관병전자잡지
Cardiovascular Disease Journal of Integrated Traditional Chinese and Western Medicine (Electronic)
2014年
11期
3-4
,共2页
儿童%脓毒症%TNF-α%IL-8%IFN-γ
兒童%膿毒癥%TNF-α%IL-8%IFN-γ
인동%농독증%TNF-α%IL-8%IFN-γ
Children%Sepsis%TNF alpha%IL - 8%IFN - gamma
目的：研究促炎因子肿瘤坏死因子（TNF-α）在脓毒症患儿标准化治疗过程中的变化情况。方法设立对照分析，脓毒症患儿50例为实验组进行标准化治疗，测定入院第1天、第4天和第7天以及出院或死亡当天外周血TNF-α含量和简化危重评分PCIS；对照组选择健康体检儿童10例，测定外周血TNF-α含量。结果对照组TNF-α含量均在正常范围内；实验组TNF-α在第1天、第4天、第7天和死亡当天时间的含量逐渐降低，组内两两比较差异有统计学意义（P＜0.05）；实验组死亡1例，为感染性休克合并急性肾功能衰竭患者；实验组平均住院治疗时间为13.5 d。结论 TNF-α为脓毒症患儿促炎因子之一，可作为诊断脓毒症的辅助指标，同时也可作为判断脓毒症疗效的手段。
目的：研究促炎因子腫瘤壞死因子（TNF-α）在膿毒癥患兒標準化治療過程中的變化情況。方法設立對照分析，膿毒癥患兒50例為實驗組進行標準化治療，測定入院第1天、第4天和第7天以及齣院或死亡噹天外週血TNF-α含量和簡化危重評分PCIS；對照組選擇健康體檢兒童10例，測定外週血TNF-α含量。結果對照組TNF-α含量均在正常範圍內；實驗組TNF-α在第1天、第4天、第7天和死亡噹天時間的含量逐漸降低，組內兩兩比較差異有統計學意義（P＜0.05）；實驗組死亡1例，為感染性休剋閤併急性腎功能衰竭患者；實驗組平均住院治療時間為13.5 d。結論 TNF-α為膿毒癥患兒促炎因子之一，可作為診斷膿毒癥的輔助指標，同時也可作為判斷膿毒癥療效的手段。
목적：연구촉염인자종류배사인자（TNF-α）재농독증환인표준화치료과정중적변화정황。방법설립대조분석，농독증환인50례위실험조진행표준화치료，측정입원제1천、제4천화제7천이급출원혹사망당천외주혈TNF-α함량화간화위중평분PCIS；대조조선택건강체검인동10례，측정외주혈TNF-α함량。결과대조조TNF-α함량균재정상범위내；실험조TNF-α재제1천、제4천、제7천화사망당천시간적함량축점강저，조내량량비교차이유통계학의의（P＜0.05）；실험조사망1례，위감염성휴극합병급성신공능쇠갈환자；실험조평균주원치료시간위13.5 d。결론 TNF-α위농독증환인촉염인자지일，가작위진단농독증적보조지표，동시야가작위판단농독증료효적수단。
Objective To study the proinflammatory cytokine tumor necrosis factor (TNF-α) therapy in children with sepsis in the standardization process changes.Methods The establishment of comparative analysis, 50 cases of children with sepsis standardized treatment for the experimental group, measured one day admission, the first four days and day 7 and the day of discharge or death peripheral blood TNF-α content and simplify critical score PCIS; selecting healthy children in the control group 10 cases, the content of TNF-α was measured in peripheral blood.Results The control group TNF-α levels were within the normal range; TNF-α in the experimental group, one day, four day, day 7 content and Tx time decreased, the group was statistically significant pairwise comparison(P<0.05); the experimental group died one case, for septic shock in patients with acute renal failure; the experimental group, the average hospitalization time was 13.5 days.Conclusion TNF-α is one of pro-inflammatory cytokines in children with sepsis, sepsis can be used as a diagnostic aid targets, but also could be used as a means of treatment of sepsis.
