CAJ | 학술논문

破骨细胞是参与骨改建过程的关键细胞。近年来，越来越多的证据表明人体不同部位的破骨细胞生物学特性存在着差异，即破骨细胞异质性。但破骨细胞异质性的产生机制尚不明确，不同部位参与诱导破骨细胞形成的成骨细胞存在差异；不同部位破骨细胞所黏附的骨基质结构及组成成分不同；不同部位破骨前体细胞不同，可能是其产生的机制。
파골세포시삼여골개건과정적관건세포。근년래，월래월다적증거표명인체불동부위적파골세포생물학특성존재착차이，즉파골세포이질성。단파골세포이질성적산생궤제상불명학，불동부위삼여유도파골세포형성적성골세포존재차이；불동부위파골세포소점부적골기질결구급조성성분불동；불동부위파골전체세포불동，가능시기산생적궤제。
Osteoclasts play a key role in bone remolding. During the last decade, several studies have demonstrated the existence of bone-site-specific biological characteristics of osteoclasts, which is defined as osteoclast heterogeneity. However, the mechanism of such heterogeneity is, still unclear. There are three hypotheses that could explain osteoclast heterogeneity. First, osteoclast heterogeneity may be due to differences in the osteoblasts that harbor the different bone sites and are involved in the generation of osteoclasts. Second, the heterogeneity may be induced by differences in the composition of the bone where osteoclasts attach to. Third, osteoclast heterogeneity results from different osteoclast precursors.