CAJ | 학술논문

目的：评价1550 nm铒玻璃点阵激光联合重组人酸性成纤维细胞生长因子（ rh-aFGF）对痤疮凹陷性瘢痕的临床疗效与安全性。方法：将2012年2月—2013年10月124例面部痤疮凹陷性瘢痕患者以随机数字表法分为治疗组、对照组各62例。对照组给予1550 nm铒玻璃点阵激光治疗联合术后抗菌药物、冰敷治疗。治疗组在对照组基础上加用rh-aFGF进行治疗。每隔3周治疗1次，共治疗3次。于第12周评价疗效，观察治疗瘢痕的临床疗效、并发症等。结果：采用rh-aFGF干预后，治疗组患者术后水肿、渗出、红斑、疼痛及灼烧感的评分分别为（1.6±0.7）、（1.4±0.5）、（1.2±0.3）、（1.5±0.9）分，低于对照组的（2.5±0.8）、（2.2±0.6）、（2.5±0.5）、（2.7±1.0）分；治疗过程中，治疗组患者感染发生率为8.1％（5／62），低于对照组的37.1％（23／62）；治疗组患者用药后创面痊愈率[54.8％（34／62）相比22.6％（14／62）]、总有效率[90.3％（56／62）相比59.7％（37／62）]均高于对照组；治疗组患者结痂时间[（2.6±1.9）d相比（4.1±2.0）d]、脱痂时间[（6.8±0.9） d相比（9.1±1.0） d]、完全愈合时间[（7.7±2.1） d相比（13.5±2.4） d]均短于对照组，2组上述指标的差异均有统计学意义（P＜0.05）。治疗组患者喷雾换药时仅5例发生瘙痒，2组患者均无其他明显不良反应发生。结论：rh-aFGF治疗痤疮凹陷性瘢痕，有利于凹陷性瘢痕的填充，同时可减少1550 nm铒玻璃点阵激光所致的并发症。
목적：평개1550 nm이파리점진격광연합중조인산성성섬유세포생장인자（ rh-aFGF）대좌창요함성반흔적림상료효여안전성。방법：장2012년2월—2013년10월124례면부좌창요함성반흔환자이수궤수자표법분위치료조、대조조각62례。대조조급여1550 nm이파리점진격광치료연합술후항균약물、빙부치료。치료조재대조조기출상가용rh-aFGF진행치료。매격3주치료1차，공치료3차。우제12주평개료효，관찰치료반흔적림상료효、병발증등。결과：채용rh-aFGF간예후，치료조환자술후수종、삼출、홍반、동통급작소감적평분분별위（1.6±0.7）、（1.4±0.5）、（1.2±0.3）、（1.5±0.9）분，저우대조조적（2.5±0.8）、（2.2±0.6）、（2.5±0.5）、（2.7±1.0）분；치료과정중，치료조환자감염발생솔위8.1％（5／62），저우대조조적37.1％（23／62）；치료조환자용약후창면전유솔[54.8％（34／62）상비22.6％（14／62）]、총유효솔[90.3％（56／62）상비59.7％（37／62）]균고우대조조；치료조환자결가시간[（2.6±1.9）d상비（4.1±2.0）d]、탈가시간[（6.8±0.9） d상비（9.1±1.0） d]、완전유합시간[（7.7±2.1） d상비（13.5±2.4） d]균단우대조조，2조상술지표적차이균유통계학의의（P＜0.05）。치료조환자분무환약시부5례발생소양，2조환자균무기타명현불량반응발생。결론：rh-aFGF치료좌창요함성반흔，유리우요함성반흔적전충，동시가감소1550 nm이파리점진격광소치적병발증。
OBJECTIVE:To evaluate the efficacy and safety of 1550 nm erbium glass fractional laser combined with recombinant human acidic fibroblast growth factor ( rh-aFGF) for depressed acne scar .METHODS:Between February 2012 and October 2013, a total of 124 patients with facial acne scar depressions were randomized to either treatment group or control group of 62 cases each treated with 1550 nm erbium glass fractional laser therapy combined with laser surgery antibiotics plus ice compress therapy , whereas the treatment group received add-on rh-aFGF with treatment performed once every three weeks ( 3 times in total ) .The curative efficacy on scar treatment and complications were evaluated at 12 weeks.RESULTS: After rh-aFGF intervention, the scores for postoperative edema , exudate, erythema , burning sensation were significantly lower in the treatment group than in the control group [ ( 1.6 ±0.7 ) scores vs.(2.5 ±0.8) scores,(1.4 ±0.5) scores vs.(2.2 ±0.6) scores,(1.2 ±0.3) scores vs.(2.5 ±0.5) scores and (1.5 ±0.9) scores vs.(2.7 ±1.0) scores,respectively].The incidence of infection duration treatment process in the treatment group was significantly lower than in the control group [ 8.1% ( 5/62 ) vs.37.1%(23/62)]; the cure rate of woundand the total effective rate were all significantly higher in the treatment group than in the control group [54.8%(34/62) vs.22.6%(14/62) and 90.3%(56/62) vs.59.7%(37/62)];the incrustation time, decrustation time, and complete healing time [(2.6 ±1.9) days vs.(4.1 ±2.0)days), (6.8 ±0.9) days vs. (9.1 ±1.0) days and (7.7 ±2.1) days vs.(13.5 ±2.4) days] were all significantly less in the treatment group than in the control group ( P<0.05 for all ); except for itching noted in 5 cases in the treatment group during mist spray dressing change , no other significant adverse drug reactions were noted for the two groups .CONCLUSIONS:rh-aFGF treatment of acne scar depressions contributed to the healing of the depressed scars and reducing of the complications induced by 1550nm erbium glass fractional laser treatment .