中国医院用药评价与分析
中國醫院用藥評價與分析
중국의원용약평개여분석
EVALUATION AND ANAL YSIS OF DRUG-USE IN HOSPITALS OF CHINA
2015年
1期
131-133,134
,共4页
奥沙利铂%过敏反应%文献分析
奧沙利鉑%過敏反應%文獻分析
오사리박%과민반응%문헌분석
Oxaliplatin%Allergic reactions%Literature analysis
目的：探讨奥沙利铂致过敏反应的特点，为临床安全用药提供参考。方法：检索国内医药期刊中有关奥沙利铂致过敏反应的文献报道，从患者年龄与性别、化疗方案、过敏反应程度、过敏反应发生时间及临床表现等方面进行统计分析。结果：共检索到奥沙利铂致过敏反应相关文献20篇，涉及病例55例。50例（占90.91％）患者在用药30 min内出现过敏症状；发生过敏反应的中位周期为第5周期，中位累积剂量为540 mg／m2；多数为Ⅱ度过敏反应（32例，占58.18％）；临床表现以皮肤及其附件损害（29例次，占总计104例次的27.88％）、呼吸系统损害（28例次，占总计104例次的26.92％）最为常见。结论：奥沙利铂致过敏反应可发生于化疗的任一周期，故临床应用奥沙利铂时应加强监测，密切观察，一旦出现过敏反应应立即处理。
目的：探討奧沙利鉑緻過敏反應的特點，為臨床安全用藥提供參攷。方法：檢索國內醫藥期刊中有關奧沙利鉑緻過敏反應的文獻報道，從患者年齡與性彆、化療方案、過敏反應程度、過敏反應髮生時間及臨床錶現等方麵進行統計分析。結果：共檢索到奧沙利鉑緻過敏反應相關文獻20篇，涉及病例55例。50例（佔90.91％）患者在用藥30 min內齣現過敏癥狀；髮生過敏反應的中位週期為第5週期，中位纍積劑量為540 mg／m2；多數為Ⅱ度過敏反應（32例，佔58.18％）；臨床錶現以皮膚及其附件損害（29例次，佔總計104例次的27.88％）、呼吸繫統損害（28例次，佔總計104例次的26.92％）最為常見。結論：奧沙利鉑緻過敏反應可髮生于化療的任一週期，故臨床應用奧沙利鉑時應加彊鑑測，密切觀察，一旦齣現過敏反應應立即處理。
목적：탐토오사리박치과민반응적특점，위림상안전용약제공삼고。방법：검색국내의약기간중유관오사리박치과민반응적문헌보도，종환자년령여성별、화료방안、과민반응정도、과민반응발생시간급림상표현등방면진행통계분석。결과：공검색도오사리박치과민반응상관문헌20편，섭급병례55례。50례（점90.91％）환자재용약30 min내출현과민증상；발생과민반응적중위주기위제5주기，중위루적제량위540 mg／m2；다수위Ⅱ도과민반응（32례，점58.18％）；림상표현이피부급기부건손해（29례차，점총계104례차적27.88％）、호흡계통손해（28례차，점총계104례차적26.92％）최위상견。결론：오사리박치과민반응가발생우화료적임일주기，고림상응용오사리박시응가강감측，밀절관찰，일단출현과민반응응립즉처리。
OBJECTIVE:To explore the characteristics of the allergic reactions induced by Oxaliplatin for clinical reference of safe medication .METHODS: The reports of oxaliplatin-induced allergic reactions retrieved in domestic medicinal journals were statistically analyzed in respect of patients'age and sex , chemotherapy regimen , degree , onset and the clinical manifestations etc of the allergic reaction .RESULTS:A total of 20 papers involving 55 allergic cases induced by oxaliplatin were retrieved , with allergic reaction appeared in 50 ( 90.91%) within 30 min after drug administration;on average , the allergic reactions occurred in the fifth cycle of oxaliplatin-containing therapy with median cumulative dose of 540 mg/m2; most allergic reactions were defined as degree Ⅱ( 32 cases, 58.18%) . Lesions of skin and its appendants (29/104 episodes, 27.88%) and respiratory symptoms (28/104, 26.92%) were the most common clinical manifestation .CONCLUSIONS: Allergic reactions induced by oxaliplatin may occur in any one cycle of chemotherapy;hence , monitoring on oxaliplatin-induced allergic reactions should be strengthened so as to take immediate action in case of allergic reaction .
