CAJ | 학술논문

目的：：探讨缺血修饰白蛋白(IMA)在急性肺栓塞(acute pulmonary embolism,APE)诊断中的应用价值。方法：选择30例经CT肺动脉造影确诊的急性肺栓塞患者作为实验组,并入选30例健康体检者作为对照组,采用白蛋白钴结合实验测定血清中缺血修饰白蛋白水平,通过绘制受试者工作曲线( ROC)获得区分急性肺栓塞患者与健康体检者的最适cut-off值。结果：实验组IMA值明显高于对照组,差异有统计学意义(P<0.01)；根据ROC曲线,IMA值的最佳诊断界值为65.38 U/ml,此时诊断急性肺栓塞的敏感度83.3%,特异度80.0%。将急性肺栓塞分为高危、中危、低危组,各组之间差异有统计学意义(P<0.05)。结论：缺血修饰白蛋白是一个灵敏的缺血性生物标志物,有助于急性肺栓塞的早期诊断,同时有助于急性肺栓塞的危险分层。
목적：：탐토결혈수식백단백(IMA)재급성폐전새(acute pulmonary embolism,APE)진단중적응용개치。방법：선택30례경CT폐동맥조영학진적급성폐전새환자작위실험조,병입선30례건강체검자작위대조조,채용백단백고결합실험측정혈청중결혈수식백단백수평,통과회제수시자공작곡선( ROC)획득구분급성폐전새환자여건강체검자적최괄cut-off치。결과：실험조IMA치명현고우대조조,차이유통계학의의(P<0.01)；근거ROC곡선,IMA치적최가진단계치위65.38 U/ml,차시진단급성폐전새적민감도83.3%,특이도80.0%。장급성폐전새분위고위、중위、저위조,각조지간차이유통계학의의(P<0.05)。결론：결혈수식백단백시일개령민적결혈성생물표지물,유조우급성폐전새적조기진단,동시유조우급성폐전새적위험분층。
Objective:To discuss the value of ischemia modified albumin ( IMA) in the diagnosis of acute pulmonary embolism (APE). Methods: The levels of plasmid IMA in 30 patients with APE (the experimental group) and 30 healthy subjects (the control group) were measured. The cut-off values of IMA in the diagnosis of APE were established with ROC curves. Results: The levels of IMA in the experimental group were significantly higher than that in the control group (P<0. 01). According to the ROC curve, the most appropriate IMA cut-off value in APE was 65. 38 U/ml(with sensitivity 83. 3%, specificity 80. 0%). The level of plasmid IMA in high risk group of APE was higher significantly than that in medium or low risk groups (P<0. 05). Conclusion: IMA may be helpful to the diagnosis and evaluation of the risk stratification of acute pulmonary embolism.