CAJ | 학술논문

目的：：观察美常安联合美沙拉嗪治疗溃疡性结肠炎( ulcerative colitis, UC)患者的疗效及对血清炎症因子的影响。方法：将226例活动期UC患者随机分为观察组114例和对照组112例,对照组给予美沙拉嗪治疗,观察组在此基础上给予美常安治疗,对比两组疗效及白介素-8(IL-8)、白介素-10(IL-10)、肿瘤坏死因子α( TNF-α)及巨噬细胞抑制因子( MIF)等血清炎症因子的变化。结果：观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前观察组IL-8、TNF-α、MIF、IL-10含量与对照组差异无统计学意义(P>0.05),治疗后IL-8和TNF-α与对照组比较降低,差异有统计学意义(P<0.05),而MIF含量与对照组比较差异无统计学意义(P>0.05)；血清中IL-10的含量在治疗后则有明显升高,且治疗组升高较对照组明显(P<0.05)。两组不良反应差异无统计学意义(P>0.05)。结论：美常安联合美沙拉嗪治疗UC可明显提高治疗有效率,两者具有药物协同作用,能更好地控制病情,有较大的临床应用价值。
목적：：관찰미상안연합미사랍진치료궤양성결장염( ulcerative colitis, UC)환자적료효급대혈청염증인자적영향。방법：장226례활동기UC환자수궤분위관찰조114례화대조조112례,대조조급여미사랍진치료,관찰조재차기출상급여미상안치료,대비량조료효급백개소-8(IL-8)、백개소-10(IL-10)、종류배사인자α( TNF-α)급거서세포억제인자( MIF)등혈청염증인자적변화。결과：관찰조총유효솔현저고우대조조,차이유통계학의의(P<0.05)。치료전관찰조IL-8、TNF-α、MIF、IL-10함량여대조조차이무통계학의의(P>0.05),치료후IL-8화TNF-α여대조조비교강저,차이유통계학의의(P<0.05),이MIF함량여대조조비교차이무통계학의의(P>0.05)；혈청중IL-10적함량재치료후칙유명현승고,차치료조승고교대조조명현(P<0.05)。량조불량반응차이무통계학의의(P>0.05)。결론：미상안연합미사랍진치료UC가명현제고치료유효솔,량자구유약물협동작용,능경호지공제병정,유교대적림상응용개치。
Objective:To evaluate the curative effect of Medilac-s capsule combined with mesala-zine and the influence on inflammatory factors in patients with ulcerative colitis. Methods: Two hundred and twenty six cases with active ulcerative colitis were randomly divided into the observa-tion group ( n=114 ) and the control group ( n=112 ) . The observation group were treated with Medilac-s capsule combined with mesalazine while the control group were only treated with mesala-zine. The curative effects in the two groups were compared. And the changes of IL-8, TNF-α,MIF and IL-10 in serum from patients with ulcerative colitis in the two groups were also compared. Results: The total efficiency in the observation group was higher than the control group and the difference was statistically significant ( P<0 . 05 ) . The concentrations of IL-8 , TNF-α, MIF and IL-10 in the two groups were not significantly different before treatment ( P>0 . 05 ) . The concen-trations of IL-8 and TNF-α were more lower in the observation group than the control group ( P<0 . 05 ) , while IL-10 was reverse after treatment ( P <0 . 05 ) . MIF was lower in the observation group than control group, but there was no statistics significance (P>0. 05). The adverse reac-tions in the two group were similar ( P>0 . 05 ) . Conclusion:Medilac-s capsule combined with me-salazine could improve the effective rate in patients with active ulcerative colitis. The two drugs had synergistic effect and could control pathogenetic condition of patients with active ulcerative co-litis. The two drugs have biggish clinical application values and good application prospect.