CAJ | 학술논문

目的：了解中国女性宫颈人乳头瘤病毒（HPV）感染状况及型别分布特征。方法以PubMed、中国知网、万方数据库为检索源，系统检索2004—2013年公开发表的中英文文献，摘录相关信息。分别将全国以及7个地理区域 HPV 感染研究的统计数据进行数据分析。结果符合纳入标准的数据覆盖全国所有省份和地区，样本量共计661658例，年龄范围16~87岁。共纳入文献245篇，我国女性人群宫颈 HPV 感染率为25.0％，感染率最高的6个高危型别依次为 HPV16、HPV52、HPV58、HPV18、HPV33和 HPV31。我国所有地区以 HPV16为主要感染型别，HPV52和 HPV58的检出率明显高于 HPV18，而 HPV35和 HPV45检出率较低。结论 HPV 感染型别分布有明显地域性，我国的统计数据与世界范围的统计数据有明显差异。我国7个地理区域间感染型别分布也有差异。
목적：료해중국녀성궁경인유두류병독（HPV）감염상황급형별분포특정。방법이PubMed、중국지망、만방수거고위검색원，계통검색2004—2013년공개발표적중영문문헌，적록상관신식。분별장전국이급7개지리구역 HPV 감염연구적통계수거진행수거분석。결과부합납입표준적수거복개전국소유성빈화지구，양본량공계661658례，년령범위16~87세。공납입문헌245편，아국녀성인군궁경 HPV 감염솔위25.0％，감염솔최고적6개고위형별의차위 HPV16、HPV52、HPV58、HPV18、HPV33화 HPV31。아국소유지구이 HPV16위주요감염형별，HPV52화 HPV58적검출솔명현고우 HPV18，이 HPV35화 HPV45검출솔교저。결론 HPV 감염형별분포유명현지역성，아국적통계수거여세계범위적통계수거유명현차이。아국7개지리구역간감염형별분포야유차이。
Objective To analyze the genotype distribution of human papillomavirus( HPV) strains and their epidemiological characteristics in cervixes of Chinese females. Methods Pertinent litera-tures published during 2004 to 2013 were screened from PubMed,China National Knowledge Infrastructure (CNKI)and Wanfang database for data analysis. Results There were 245 studies screened out for the me-ta-analysis. A total of 661 658 cases met the inclusion criteria,ranging from 16 to 87 years old. All prov-inces and territories of China were covered by the data. The overall rate of HPV infection in cervix was 25. 0% among Chinese females. The predominant high risk genotype of human papillomavirus strains was HPV16,followed by HPV52,HPV58,HPV18,HPV33 and HPV31. HPV52 and HPV58 genotypes were more prevalent than HPV18 genotype. HPV35 and HPV45 genotypes were less popular. Conclusion The study suggested that the HPV infection showed obvious regional differences in genotypes. The genotype dis-tribution of HPV infection in China was different from that in other regions of the world. There were differ-ences with genotype distribution of HPV strains among seven geographic regions of China.