CAJ | 학술논문

目的：系统评价他汀类药物对结直肠癌的发病率及病死率的影响。方法使用Medline等数据库收集他汀类药物与结直肠肿瘤相关的文献，筛选高质量文献，分别计算RR或OR值以及95%CI等，分析他汀类药物预防结直肠癌及结直肠腺瘤的作用，运用漏斗图评价发表偏倚。结果共纳入30项研究，研究对象2417713例。他汀类药物预防结直肠癌的森林图提示存在统计学差异（RR=0.87，95%CI：0.77-0.99，P=0.03），他汀类药物预防结直肠腺瘤的森林图不存在统计学差异（OR=0.61，95%CI：0.31-1.22，P=0.16），漏斗图分析各项研究未发现发表偏倚。结论他汀类药物对结直肠癌可能起到一定的化学预防作用，而对结直肠腺瘤的作用有待进一步研究。
목적：계통평개타정류약물대결직장암적발병솔급병사솔적영향。방법사용Medline등수거고수집타정류약물여결직장종류상관적문헌，사선고질량문헌，분별계산RR혹OR치이급95%CI등，분석타정류약물예방결직장암급결직장선류적작용，운용루두도평개발표편의。결과공납입30항연구，연구대상2417713례。타정류약물예방결직장암적삼림도제시존재통계학차이（RR=0.87，95%CI：0.77-0.99，P=0.03），타정류약물예방결직장선류적삼림도불존재통계학차이（OR=0.61，95%CI：0.31-1.22，P=0.16），루두도분석각항연구미발현발표편의。결론타정류약물대결직장암가능기도일정적화학예방작용，이대결직장선류적작용유대진일보연구。
Objective Aim of this study is to explore the association between statin use and colorectal neoplasm risk through meta-analysis based on published studies. Methods A comprehensive literature search was undertaken through August 2014 looking for eligible studies through Medline and so on. Pooled relative risk (RR) estimates and 95%confidence intervals (CIs) were used to calculate estimated effect. Then, the po-tential presence of publication bias and study heterogeneity was assessed. Result A total of 30 studies, involv-ing 2,417,713 subjects, contributed to the analysis. Overall, statin use was associated with a modest reduction in the risk of colorectal cancer (RR=0.87, 95%CI:0.77-0.99, P=0.03). However, we did not find significant evidence of statin use and colorectal adenoma (OR=0.61, 95%CI:0.31-1.22, P=0.16). Publication bias was not be detected by the funnel plot. Conclusion Statin use was associated with a modest reduced risk of col-orectal cancer. However, further targeted research of the association between statin and colorectal adenoma is warranted.