现代消化及介入诊疗
現代消化及介入診療
현대소화급개입진료
MODERN DIGESTION & INTERVENTION
2014年
6期
351-353
,共3页
甲胎蛋白%血管内皮生长因子%p53抗体%原发性肝细胞癌
甲胎蛋白%血管內皮生長因子%p53抗體%原髮性肝細胞癌
갑태단백%혈관내피생장인자%p53항체%원발성간세포암
Alpha fetoprotein%Vascular endothelial growth factor%p53 antibody%Primary hepatocellular carcinoma
目的：探讨血清甲胎蛋白（AFP）、血管内皮生长因子（VEGF）、p53抗体诊断原发性肝细胞癌（HCC ）的临床价值。方法选取2011年9月至2014年6月我院收治的79例HCC患者作为病例组，选取同期我院收治的65例肝硬化（HC）患者作为对照1组，另外选取同期我院体检科确诊的72例健康对照者作为对照2组，所有患者均接受AFP、VEGF、p53抗体测定，其中AFP测定采用电化学发光法， VEGF、p53抗体测定采用酶联免疫吸附试验（ELISA）。结果①病例组血清AFP、VEGF、p53抗体显著高于对照1组（P＜0.01），对照1组血清AFP、VEGF、p53抗体显著高于对照2组（P＜0.01）。②绘制受试者工作特征（ROC）曲线，得到AFP、VEGF、p53抗体诊断HCC的ROC曲线下面积（AUC）分别为0.843（95% CI，0.738～0.905）、0.827（95% CI，0.731～0.899）、0.634（95% CI，0.515～0.756），AFP-AUC 与VEGF-AUC相比差异无统计学意义（P＞0.05），p53抗体-AUC显著低于AFP-AUC与VEGF-AUC，差异有统计学意义（P＜0.01）。由ROC曲线可知，AFP、VEGF、p53抗体诊断HCC的最佳cut-off值分别为197μg/L、233 ng/L、0.63 kU/L，由此得知这3个指标诊断HCC的灵敏度、特异度分别为84.81%、87.59%，82.28%、89.78%，65.82%、86.13%。结论血清AFP与VEGF诊断HCC的临床性能相当，而p53抗体诊断HCC的灵敏度较低。
目的：探討血清甲胎蛋白（AFP）、血管內皮生長因子（VEGF）、p53抗體診斷原髮性肝細胞癌（HCC ）的臨床價值。方法選取2011年9月至2014年6月我院收治的79例HCC患者作為病例組，選取同期我院收治的65例肝硬化（HC）患者作為對照1組，另外選取同期我院體檢科確診的72例健康對照者作為對照2組，所有患者均接受AFP、VEGF、p53抗體測定，其中AFP測定採用電化學髮光法， VEGF、p53抗體測定採用酶聯免疫吸附試驗（ELISA）。結果①病例組血清AFP、VEGF、p53抗體顯著高于對照1組（P＜0.01），對照1組血清AFP、VEGF、p53抗體顯著高于對照2組（P＜0.01）。②繪製受試者工作特徵（ROC）麯線，得到AFP、VEGF、p53抗體診斷HCC的ROC麯線下麵積（AUC）分彆為0.843（95% CI，0.738～0.905）、0.827（95% CI，0.731～0.899）、0.634（95% CI，0.515～0.756），AFP-AUC 與VEGF-AUC相比差異無統計學意義（P＞0.05），p53抗體-AUC顯著低于AFP-AUC與VEGF-AUC，差異有統計學意義（P＜0.01）。由ROC麯線可知，AFP、VEGF、p53抗體診斷HCC的最佳cut-off值分彆為197μg/L、233 ng/L、0.63 kU/L，由此得知這3箇指標診斷HCC的靈敏度、特異度分彆為84.81%、87.59%，82.28%、89.78%，65.82%、86.13%。結論血清AFP與VEGF診斷HCC的臨床性能相噹，而p53抗體診斷HCC的靈敏度較低。
목적：탐토혈청갑태단백（AFP）、혈관내피생장인자（VEGF）、p53항체진단원발성간세포암（HCC ）적림상개치。방법선취2011년9월지2014년6월아원수치적79례HCC환자작위병례조，선취동기아원수치적65례간경화（HC）환자작위대조1조，령외선취동기아원체검과학진적72례건강대조자작위대조2조，소유환자균접수AFP、VEGF、p53항체측정，기중AFP측정채용전화학발광법， VEGF、p53항체측정채용매련면역흡부시험（ELISA）。결과①병례조혈청AFP、VEGF、p53항체현저고우대조1조（P＜0.01），대조1조혈청AFP、VEGF、p53항체현저고우대조2조（P＜0.01）。②회제수시자공작특정（ROC）곡선，득도AFP、VEGF、p53항체진단HCC적ROC곡선하면적（AUC）분별위0.843（95% CI，0.738～0.905）、0.827（95% CI，0.731～0.899）、0.634（95% CI，0.515～0.756），AFP-AUC 여VEGF-AUC상비차이무통계학의의（P＞0.05），p53항체-AUC현저저우AFP-AUC여VEGF-AUC，차이유통계학의의（P＜0.01）。유ROC곡선가지，AFP、VEGF、p53항체진단HCC적최가cut-off치분별위197μg/L、233 ng/L、0.63 kU/L，유차득지저3개지표진단HCC적령민도、특이도분별위84.81%、87.59%，82.28%、89.78%，65.82%、86.13%。결론혈청AFP여VEGF진단HCC적림상성능상당，이p53항체진단HCC적령민도교저。
Objective To evaluate the clinical value of serum alpha fetoprotein (AFP), vascular endothe-lial growth factor (VEGF), p53 antibody in diagnosis of primary hepatocellular carcinoma (HCC). Methods Seventy nine patients with HCC (HCC group) from 2011 September to 2014 June in our hospital were selected, and 65 patients with liver cirrhosis (HC group) and 72 healthy subjects (HS group) served as control groups. AFP (measured by electrochemical luminescence method), VEGF and p53 antibody (measured by ELISA) were determined in all participants. Results AFP, VEGF, p53 antibody were significantly higher in HCC group than that in HC group (P<0.01), and AFP, VEGF, p53 antibody were significantly higher in HC group than that in HS group (P<0.01). The drawing of the receiver operating characteristic (ROC) curve was made; we got the ROC curve area of AFP, VEGF, and p53 antibody for the diagnosis of HCC. AFP-AUC was 0.843 (95%CI, 0.738~0.905), VEGF-AUC 0.827 (95%CI, 0.731~0.899), and p53 antibody-AUC 0.634 (95%CI, 0.515~0.756). After comparison, only p53 antibody-AUC was significantly lower than that of AFP-AUC and VEGF-AUC (P<0.01). By the ROC curves, the best cut-off values of AFP, VEGF, and p53 antibody in the diagnosis of HCC were 197 g/L, 233ng/L, and 0.63kU/L, respectively. The sensitivity and specificity in the di-agnosis of HCC were 84.81%and 87.59%for AFP, 82.28%and 89.78%for VEGF, 65.82%and 86.13%for p53 antibody, respectively. Conclusion The diagnostic power of serum AFP and VEGF for HCC was equiva-lent, and the sensitivity of p53 antibody in the diagnosis of HCC was lower.
