CAJ | 학술논문

采用衍生方式建立了化妆品中壬二酸的样品处理方法，确立了壬二酸衍生物的气相色谱检测方法。结果表明当衍生剂为硫酸和乙醇、衍生时间为1 h、衍生温度为70℃时，壬二酸的衍生效果比较好。采用 DB-1毛细管色谱柱，升温程序为初温80℃、20℃／min 升至300℃后保留3 min，壬二酸衍生物能够得到较好分离。用氢火焰离子化检测器检测，外标法定量。壬二酸衍生物在20～1000 mg／L 范围内线性关系良好，决定系数 r2＝0．9996。气相色谱法定性检出限和定量下限分别为50．0和100．0 mg／kg，回收率为84．9％～105．8％，RSD＜5％。68批次样品检测结果显示：在标称含有壬二酸的2个样品中，仅有1个检出了壬二酸，其质量比为117 mg／kg，其余67种样品均未检出壬二酸。
채용연생방식건립료화장품중임이산적양품처리방법，학립료임이산연생물적기상색보검측방법。결과표명당연생제위류산화을순、연생시간위1 h、연생온도위70℃시，임이산적연생효과비교호。채용 DB-1모세관색보주，승온정서위초온80℃、20℃／min 승지300℃후보류3 min，임이산연생물능구득도교호분리。용경화염리자화검측기검측，외표법정량。임이산연생물재20～1000 mg／L 범위내선성관계량호，결정계수 r2＝0．9996。기상색보법정성검출한화정량하한분별위50．0화100．0 mg／kg，회수솔위84．9％～105．8％，RSD＜5％。68비차양품검측결과현시：재표칭함유임이산적2개양품중，부유1개검출료임이산，기질량비위117 mg／kg，기여67충양품균미검출임이산。
In this study,a gas chromatography method for the determination of azelaic acid in cosmetics was established in de-rivative way.The results showed that when the derivative agent were sulfuric acid and ethanol,derivative time was 1 h,tem-perature was 70 ℃,the derivative effect was good.By using DB-1 capillary column,when the temperature program was as fol-lows:the initial temperature 80 ℃,at rate of 20 ℃/min to 300 ℃,the retention time 3 min,the azelaic acid derivatives could be well separated.The hydrogen flame ionization detector was used and azelaic acid was quantified by external standard meth-od.In the range of 20 to 1 000 mg/L,the linear relationship of azelaic acid derivatives were good,the correlation coefficient r2=0.9996,qualitative detection limit was 50.0 mg/kg,quantitative limit was 100 mg/kg.The recovery rate was 84.9% to 105.8%,RSD<5%.The test results of 68 batches of samples showed that only one was detected among 2 samples claimed containing azelaic acid,and its mass ratio was 117 mg/kg,the other 67 samples were no azelaic acid detected.