CAJ | 학술논문

目的：分析深圳市罗湖辖区结核病患者分枝杆菌( Mycobacterium tuberculosis, MTB)及其L型( MTB-L)的耐药状况,探讨MTB-L感染对结核病患者耐药状况的影响。方法收集确诊的960例患者(初治916例,复治44例)痰液标本,对其中涂片染色阳性的468例标本进行培养,并对培养阳性的标本进行异烟肼、链霉素、利福平和乙胺丁醇等四种一线药物药敏试验,比较MTB和MTB-L耐药率的差异。结果 MTB-L和MTB对四种一线药物的单耐药率、多耐药率和耐多药率均不同；MTB-L初治始耐药率显著高于MTB初治始耐药率(46．7% vs 22．4%, P<0．05)；MTB-L复治耐药率略高于MTB复治耐药率,但差异无统计学意义(46．7% vs 33．3%, P>0．05)。结论 MTB-L感染可能与结核病患者耐药状况改变和耐药率增高有关,加强MTB-L感染监测和耐药分析是当前结核病防控的重要策略之一。
목적：분석심수시라호할구결핵병환자분지간균( Mycobacterium tuberculosis, MTB)급기L형( MTB-L)적내약상황,탐토MTB-L감염대결핵병환자내약상황적영향。방법수집학진적960례환자(초치916례,복치44례)담액표본,대기중도편염색양성적468례표본진행배양,병대배양양성적표본진행이연정、련매소、리복평화을알정순등사충일선약물약민시험,비교MTB화MTB-L내약솔적차이。결과 MTB-L화MTB대사충일선약물적단내약솔、다내약솔화내다약솔균불동；MTB-L초치시내약솔현저고우MTB초치시내약솔(46．7% vs 22．4%, P<0．05)；MTB-L복치내약솔략고우MTB복치내약솔,단차이무통계학의의(46．7% vs 33．3%, P>0．05)。결론 MTB-L감염가능여결핵병환자내약상황개변화내약솔증고유관,가강MTB-L감염감측화내약분석시당전결핵병방공적중요책략지일。
Objective To analyze the infection status of mycobacterium tuberculosis ( MTB) and mycobacte-rium tuberculosis L form ( MTB-L) in tuberculosis patients in Luohu district of Shenzhen and to investigate the effect of MTB-L infection on the resistant state in tuberculosis patients. Methods The sputum samples were collected from 960 definite tuberculosis patients (916 initial treatment and 44 re-treatment) and detected by acid-fast staining meth-od. 468 positive sample by smear staining method were cultivated, then the cultivated positive sample were carried out susceptibility test with INH, SM, RFP and EB. The statistical difference of the resistant rates of MTB and MTB-L were analyzed. Results The resistance rates of MTB and MTB-L against INH, SM, RFP and EB were obviously different. The resistance rate of initial treatment of MTB-L was sharply higher than that of MTB (46. 7% vs 22. 4%, P<0. 05). The resistance rate of re-treatment of MTB-L was slightly higher than that of MTB (46. 7% vs 33. 3%, P>0. 05). Conclusion MTB-L infection might participate in the changed resistant state and heightened resistant rate in tuberculosis patients. MTB-L infection monitoring and resistance analysis are important strategies of current tuber-culosis control.