临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2015年
3期
530-532,535
,共4页
慢性阻塞性肺疾病%肺炎%肿瘤坏死因子-α%可溶性髓样细胞触发受体-1%白细胞介素-6%ROC曲线
慢性阻塞性肺疾病%肺炎%腫瘤壞死因子-α%可溶性髓樣細胞觸髮受體-1%白細胞介素-6%ROC麯線
만성조새성폐질병%폐염%종류배사인자-α%가용성수양세포촉발수체-1%백세포개소-6%ROC곡선
chronic obstructive pulmonary disease%pneumonia%tumor necrosis factor-α%triggering receptor expressed on myeloid cells-1%interleukin-6%receiver operating characteristic curve
目的：研究肿瘤坏死因子-α( TNF-α)、可溶性髓样细胞触发受体-1( sTREM-1)、白细胞介素-6(IL-6)、降钙素原(PCT)在慢性阻塞性肺疾病(简称慢阻肺)伴肺炎患者临床诊断中的意义。方法选择36例慢阻肺伴肺炎和30例慢阻肺不伴肺炎患者,通过ELISA法检测血清TNF-α、sTREM-1、IL-6、PCT表达水平,绘制ROC曲线分析确定四种细胞炎性因子诊断慢阻肺伴肺炎的临界值,并评价其特异性、敏感性及诊断效能。结果慢阻肺疾病进展中TNF-α、sTREM-1、IL-6、PCT存在升高,并且肺炎患者高于未伴肺炎患者,差异具有显著统计学意义(P<0．01)。慢阻肺伴肺炎患者中,加重期和缓解期的TNF-α、sTREM-1、IL-6、PCT表达水平均高于对照组,差异具有统计学意义( P<0．01),且加重期TNF-α、sTREM-1、PCT水平均高于缓解期,差异具有统计学意义(P<0．01)。伴肺炎患者中,加重期和缓解期TNF-α、sTREM-1、IL-6、PCT表达水平均高于未伴肺炎患者中其相应的组别,差异具有统计学意义(P<0．01)。 TNF-α、sTREM-1诊断COPD伴肺炎的临界值依次为124.54 ng/L、118.76 ng/mL,敏感性依次为89.5%、91．4%,特异性依次为92．6%、89．3%；通过比较ROC曲线下面积大小,提示TNF-α的诊断效能和sTREM-1接近。结论血清中TNF-α、sTREM-1水平测定有助于慢阻肺伴肺炎的临床诊断。
目的：研究腫瘤壞死因子-α( TNF-α)、可溶性髓樣細胞觸髮受體-1( sTREM-1)、白細胞介素-6(IL-6)、降鈣素原(PCT)在慢性阻塞性肺疾病(簡稱慢阻肺)伴肺炎患者臨床診斷中的意義。方法選擇36例慢阻肺伴肺炎和30例慢阻肺不伴肺炎患者,通過ELISA法檢測血清TNF-α、sTREM-1、IL-6、PCT錶達水平,繪製ROC麯線分析確定四種細胞炎性因子診斷慢阻肺伴肺炎的臨界值,併評價其特異性、敏感性及診斷效能。結果慢阻肺疾病進展中TNF-α、sTREM-1、IL-6、PCT存在升高,併且肺炎患者高于未伴肺炎患者,差異具有顯著統計學意義(P<0．01)。慢阻肺伴肺炎患者中,加重期和緩解期的TNF-α、sTREM-1、IL-6、PCT錶達水平均高于對照組,差異具有統計學意義( P<0．01),且加重期TNF-α、sTREM-1、PCT水平均高于緩解期,差異具有統計學意義(P<0．01)。伴肺炎患者中,加重期和緩解期TNF-α、sTREM-1、IL-6、PCT錶達水平均高于未伴肺炎患者中其相應的組彆,差異具有統計學意義(P<0．01)。 TNF-α、sTREM-1診斷COPD伴肺炎的臨界值依次為124.54 ng/L、118.76 ng/mL,敏感性依次為89.5%、91．4%,特異性依次為92．6%、89．3%；通過比較ROC麯線下麵積大小,提示TNF-α的診斷效能和sTREM-1接近。結論血清中TNF-α、sTREM-1水平測定有助于慢阻肺伴肺炎的臨床診斷。
목적：연구종류배사인자-α( TNF-α)、가용성수양세포촉발수체-1( sTREM-1)、백세포개소-6(IL-6)、강개소원(PCT)재만성조새성폐질병(간칭만조폐)반폐염환자림상진단중적의의。방법선택36례만조폐반폐염화30례만조폐불반폐염환자,통과ELISA법검측혈청TNF-α、sTREM-1、IL-6、PCT표체수평,회제ROC곡선분석학정사충세포염성인자진단만조폐반폐염적림계치,병평개기특이성、민감성급진단효능。결과만조폐질병진전중TNF-α、sTREM-1、IL-6、PCT존재승고,병차폐염환자고우미반폐염환자,차이구유현저통계학의의(P<0．01)。만조폐반폐염환자중,가중기화완해기적TNF-α、sTREM-1、IL-6、PCT표체수평균고우대조조,차이구유통계학의의( P<0．01),차가중기TNF-α、sTREM-1、PCT수평균고우완해기,차이구유통계학의의(P<0．01)。반폐염환자중,가중기화완해기TNF-α、sTREM-1、IL-6、PCT표체수평균고우미반폐염환자중기상응적조별,차이구유통계학의의(P<0．01)。 TNF-α、sTREM-1진단COPD반폐염적림계치의차위124.54 ng/L、118.76 ng/mL,민감성의차위89.5%、91．4%,특이성의차위92．6%、89．3%；통과비교ROC곡선하면적대소,제시TNF-α적진단효능화sTREM-1접근。결론혈청중TNF-α、sTREM-1수평측정유조우만조폐반폐염적림상진단。
Objective To evaluate the significance of tumor necrosis factor-α ( TNF-α) , soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), interleukin-6 (IL-6) and procalcitonin (PCT) levels in the ser-um for the diagnosis of pneumonia complicated with chronic obstructive pulmonary disease ( COPD) . Methods En-zyme-linked immunosorbent assay (ELISA) was adopted to detect the levels of TNF-α, sTREM-1, IL-6 and PCT in serum of 36 patients with pneumonia complicated with COPD and 30 COPD patients. The receiver operating charac-teristic ( ROC) curves were used to detect the cut-off value and analyze the specificity, sensitivity and diagnostic effi-ciency. Results The serum levels of TNF-α, sTREM-1, IL-6 and PCT increased in both groups, and the increase was more pronounced in the COPD patients complicated with pneumonia than in the COPD group (P<0. 01). When the cut-off value of TNF-αand sTREM-1 were 124. 54 ng/L and 118. 76 ng/mL respectively, the sensitivity for TNF-αand sTREM-1 in the diagnosis of Tibetan tuberculous meningitis were 89. 5% and 91. 4%, the specificity for TNF-α and sTREM-1 were 92. 6% and 89. 3%, respectively. And the diagnostic efficiency of TNF-αwas similar to that of sTREM-1 by comparison the area under the curve. Conclusion The detection of TNF-α and sTREM-1 in serum is helpful in the diagnosis of pneumonia complicated with chronic obstructive pulmonary disease.
