临床肺科杂志
臨床肺科雜誌
림상폐과잡지
JOUNAL OF CLINICAL PULMONARY MEDICINE
2015年
3期
515-517
,共3页
支气管扩张症%病原菌%耐药率%药物敏感试验
支氣管擴張癥%病原菌%耐藥率%藥物敏感試驗
지기관확장증%병원균%내약솔%약물민감시험
bronchiectasis%pathogens%resistance rates%drug sensitivity test
目的：探讨支气管扩张症急性发作患者的感染病原菌分布及其耐药性情况。方法对本院收治的133例支气管扩张症感染加重期患者的痰培养、病原菌及药敏进行记录并分析。结果133例患者中痰培养样品出现阳性有62例，阳性率为46．6%，并从中分离得到82株菌株，且革兰阴性菌占85．4%(70/82)，革兰阳性菌占11．0%(9/82)，真菌占3．7%(3/82)。所有病原菌种主要以铜绿假单胞菌为主，占36．6%(30/82)。其次是肺炎克雷伯菌，占15．9%(13/82)，流感嗜血菌占12．2%(10/82)。药敏实验结果表明分离所得的多种革兰阴性菌均具有多重耐药性，尤其是肺炎克雷伯菌和大肠埃希菌，对环丙沙星、左氧氟沙星、氨苄西林、头孢呋辛、头孢噻肟的耐药率均>50%，显示较强的耐药能力。结论支气管扩张症急性发作患者感染的病原菌绝大多数为革兰阴性菌，且普遍耐药性较强。
目的：探討支氣管擴張癥急性髮作患者的感染病原菌分佈及其耐藥性情況。方法對本院收治的133例支氣管擴張癥感染加重期患者的痰培養、病原菌及藥敏進行記錄併分析。結果133例患者中痰培養樣品齣現暘性有62例，暘性率為46．6%，併從中分離得到82株菌株，且革蘭陰性菌佔85．4%(70/82)，革蘭暘性菌佔11．0%(9/82)，真菌佔3．7%(3/82)。所有病原菌種主要以銅綠假單胞菌為主，佔36．6%(30/82)。其次是肺炎剋雷伯菌，佔15．9%(13/82)，流感嗜血菌佔12．2%(10/82)。藥敏實驗結果錶明分離所得的多種革蘭陰性菌均具有多重耐藥性，尤其是肺炎剋雷伯菌和大腸埃希菌，對環丙沙星、左氧氟沙星、氨芐西林、頭孢呋辛、頭孢噻肟的耐藥率均>50%，顯示較彊的耐藥能力。結論支氣管擴張癥急性髮作患者感染的病原菌絕大多數為革蘭陰性菌，且普遍耐藥性較彊。
목적：탐토지기관확장증급성발작환자적감염병원균분포급기내약성정황。방법대본원수치적133례지기관확장증감염가중기환자적담배양、병원균급약민진행기록병분석。결과133례환자중담배양양품출현양성유62례，양성솔위46．6%，병종중분리득도82주균주，차혁란음성균점85．4%(70/82)，혁란양성균점11．0%(9/82)，진균점3．7%(3/82)。소유병원균충주요이동록가단포균위주，점36．6%(30/82)。기차시폐염극뢰백균，점15．9%(13/82)，류감기혈균점12．2%(10/82)。약민실험결과표명분리소득적다충혁란음성균균구유다중내약성，우기시폐염극뢰백균화대장애희균，대배병사성、좌양불사성、안변서림、두포부신、두포새우적내약솔균>50%，현시교강적내약능력。결론지기관확장증급성발작환자감염적병원균절대다수위혁란음성균，차보편내약성교강。
Objective To explore the infectious pathogens distribution and drug resistance of patients with bronchiectasis at acute episodes. Methods The sputum of 133 patients with acute exacerbation of bronchiectasis was collected and cultured to analyze the distribution and antimicrobial susceptibility of pathogens. Results 46 cases of sputum culture were positive, accounting for 46. 6%. There were 82 stains isolated from those patients, which in-cluded 85. 4% of gram-negative bacteria (70/82), 36. 6% of gram-positive bacteria (9/82) and 3. 7% of fungi. The main pathogens was Pseudomonas aeruginosa (85. 4%), followed by klebsiella pneumoniae (15. 9%) and He-mophilus influenzae (12. 2%). Gram-negative bacterium showed multiple drug resistance, which especially Klebsiel-la pneumoniae and E. Coli showed a stronger drug-resistance to ciprofloxacin, levofloxacin, ampicillin, cefuroxime and cefotaxime. Conclusion The main infectious pathogens of patients with acute exacerbation of bronchiectasis are gram-negative bacteria, showing high drug resistance. The doctor should select proper antimicrobial agents according to bacterial culture and antimicrobial susceptibility testing results during clinical therapy.
