CAJ | 학술논문

目的：探讨高敏性C反应蛋白（hs‐CRP）与急性脑梗死患者临床预后的关系。方法选取973例症状发作24 h后诊断为急性脑梗死患者，在入院当天和第7天检测血液hs‐CRP浓度，随访12个月探讨hs‐CRP与临床预后的关系。结果入院当天和第7天hs‐CRP浓度与脑梗死后12个月改良的Rankin分级（mRS）评分明显相关，mRS评分与第7天hs‐CRP浓度较入院当天hs‐CRP浓度关系更密切。结论脑梗死后第7天hs‐CRP浓度明显高于发病24 h内，提示hs‐CRP对临床预后有明显的预测作用，是急性卒中有用的标志物。
목적：탐토고민성C반응단백（hs‐CRP）여급성뇌경사환자림상예후적관계。방법선취973례증상발작24 h후진단위급성뇌경사환자，재입원당천화제7천검측혈액hs‐CRP농도，수방12개월탐토hs‐CRP여림상예후적관계。결과입원당천화제7천hs‐CRP농도여뇌경사후12개월개량적Rankin분급（mRS）평분명현상관，mRS평분여제7천hs‐CRP농도교입원당천hs‐CRP농도관계경밀절。결론뇌경사후제7천hs‐CRP농도명현고우발병24 h내，제시hs‐CRP대림상예후유명현적예측작용，시급성졸중유용적표지물。
Objective To investigate the relationship between high sensitivity C‐reactive protein and clinical prognosis in patients with acute cerebral infarction.Methods The hs‐CRP levels of 973 patients with acute cerebral infarction were detected on admission and on the seventh day and then followed up 12 months after stroke onset to investigate the correlations between hs‐CRP level and clinical prognosis.Results There were obvious correlations between the hs‐CRP level on admission and on the seventh day and the modified Rankin scale (mRS) score at 12 months after cerebral infarction. The mRS scores were more closely associated with hs‐CRP levels on the seventh hospital day than hs‐CRP levels on admission.Conclusion The hs‐CRP level on the seventh day after cerebral infarction is higher than that on admission. This result suggests that hs‐CRP can predict the clinical prognosis of stroke patients and is a useful marker of acute stroke.