中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2015年
2期
15-17
,共3页
乌灵胶囊%氟哌噻吨美利曲辛%抑郁症%安全性
烏靈膠囊%氟哌噻噸美利麯辛%抑鬱癥%安全性
오령효낭%불고새둔미리곡신%억욱증%안전성
Wuling Capsule%Flupentixol and Melitracen%Depression%Safety
目的观察乌灵胶囊与氟哌噻吨美利曲辛治疗卒中后抑郁症的临床疗效及安全性。方法入选2012‐06—疗前、治疗后4周、8周应用 HAMD评分法进行抑郁情症改善情况的评定,同时应用NIHSS评分和Barthel指数评分对2组患者抑郁症缓解情况和神经功能缺损情况进行评估;同时对2组患者治疗期间不良反应发生情况进行观察和记录。结果2组治疗后4周和8周 HAMD差异显著;治疗8周后NIHSS和BI评分均显著下降(P<0.05),观察组对比对照组下降幅度更大,且不良反应发生率较对照组低( P<0.05)。结论乌灵胶囊与氟哌噻吨美利曲辛联合应用能够明显改善脑卒中后抑郁症患者的临床症状,同时降低神经功能缺损情况,不良反应较轻。
目的觀察烏靈膠囊與氟哌噻噸美利麯辛治療卒中後抑鬱癥的臨床療效及安全性。方法入選2012‐06—療前、治療後4週、8週應用 HAMD評分法進行抑鬱情癥改善情況的評定,同時應用NIHSS評分和Barthel指數評分對2組患者抑鬱癥緩解情況和神經功能缺損情況進行評估;同時對2組患者治療期間不良反應髮生情況進行觀察和記錄。結果2組治療後4週和8週 HAMD差異顯著;治療8週後NIHSS和BI評分均顯著下降(P<0.05),觀察組對比對照組下降幅度更大,且不良反應髮生率較對照組低( P<0.05)。結論烏靈膠囊與氟哌噻噸美利麯辛聯閤應用能夠明顯改善腦卒中後抑鬱癥患者的臨床癥狀,同時降低神經功能缺損情況,不良反應較輕。
목적관찰오령효낭여불고새둔미리곡신치료졸중후억욱증적림상료효급안전성。방법입선2012‐06—료전、치료후4주、8주응용 HAMD평분법진행억욱정증개선정황적평정,동시응용NIHSS평분화Barthel지수평분대2조환자억욱증완해정황화신경공능결손정황진행평고;동시대2조환자치료기간불량반응발생정황진행관찰화기록。결과2조치료후4주화8주 HAMD차이현저;치료8주후NIHSS화BI평분균현저하강(P<0.05),관찰조대비대조조하강폭도경대,차불량반응발생솔교대조조저( P<0.05)。결론오령효낭여불고새둔미리곡신연합응용능구명현개선뇌졸중후억욱증환자적림상증상,동시강저신경공능결손정황,불량반응교경。
Objective To investigate the curative effect and safety of Wuling Capsule plus Flupentixol and Melitracen Tab‐lets on treating stroke patients with depression. Methods 84 stroke patients with depression in our hospital from June 2012 to June 2013 were randomly divided into observation group (treated with Wuling Capsule plus Flupentixol and Melitracen Tablets) and control group (treated with Flupentixol and Melitracen Tablets). The depressive‐symptom‐improvement situation of two groups was evaluated by HAMD score ,NIHSS score and Barthel index before treatment and 4 weeks ,8 weeks after treatment.The neurologic impairment of two groups was also assessed by NIHSS score and Barthel index. The curative effect and adverse reaction of two groups were compared.Results The NIHSS and BI scores of two groups had significant reduction especially in observation group 8 weeks after treatment ,and the adverse reaction incidence of observation group was lower than that of con‐trol group. Conclusion Wuling Capsule plus Flupentixol and Melitracen Tablets can significantly improve the depressive symptoms of stroke patients ,decrease patients’ neurologic impairment and reduce adverse reaction.