CAJ | 학술논문

目的：观察后肢制动不同时期单一肌梭感觉末梢放电活动的改变。方法石膏固定建立大鼠后肢制动模型，雌性大鼠随机分为后肢制动3 d组、7 d组、14 d组及对照组。用空气隔绝法，观察制动不同时期单一肌梭的自发放电、0.05 mg/ml琥珀酰胆碱灌流及牵拉至伸长位后肌梭放电活动的改变。结果后肢制动3d肌梭的自发放电活动和对琥珀酰胆碱灌流的反应明显降低（分别为P<0.01和P<0.05），制动14 d后伸长位肌梭的传入放电频率降低（P<0.01）。单个动作电位时程也随着制动时间的延长而显著延长（P<0.01）。结论后肢制动可致肌梭的传入放电活动减少，这可能与肌梭自身收缩特性的改变有关。
목적：관찰후지제동불동시기단일기사감각말소방전활동적개변。방법석고고정건립대서후지제동모형，자성대서수궤분위후지제동3 d조、7 d조、14 d조급대조조。용공기격절법，관찰제동불동시기단일기사적자발방전、0.05 mg/ml호박선담감관류급견랍지신장위후기사방전활동적개변。결과후지제동3d기사적자발방전활동화대호박선담감관류적반응명현강저（분별위P<0.01화P<0.05），제동14 d후신장위기사적전입방전빈솔강저（P<0.01）。단개동작전위시정야수착제동시간적연장이현저연장（P<0.01）。결론후지제동가치기사적전입방전활동감소，저가능여기사자신수축특성적개변유관。
Objective To investigate the changes in the afferent discharge activities of the sensory nerve endings in muscle spindles of rats with hindlimb immobilization. Methods Plaster cast was used immobilize the hindllimbs of rats. Using air-gap technique, the spontaneous discharge of the muscle spindles and its responses to perfusion with succinylcholine (0.05 mg/ml) and suspension in an extended position were observed in isolated muscle spindles from rats with hindlimb immobilization for 3, 7, and 14 days. Results The muscle spindles of rat soleus showed a sharp decrease in spontaneous discharge frequency (P<0.01) and response to succinylcholine perfusion after 3 days of hindlimb immobilization (P<0.05). Significant changes of the firing rate in an extended position was observed in rats after a 14-day immobilization (P<0.01). The duration of individual spikes was significantly prolonged following hindlimb immobilization (P<0.01). Conclusion Muscle spindle discharges decrease significantly in rats following hindlimb immobilization, which might be related to reduced contractile properties of the muscle spindle.