CAJ | 학술논문

肺动脉高压是由多种因素引起的肺血管功能及结构性异常，导致肺血管阻力增加，引发肺动脉压力升高的临床综合征。胰岛素抵抗是多种心血管疾病的重要危险因素之一，但其与肺动脉高压的关系直到近几年才受到关注。研究发现胰岛素抵抗及其伴发的高胰岛素血症、血脂紊乱、炎症反应和氧化应激，可引起肺血管紧张性增高、血管内皮功能受损以及肺血管重塑等，与肺动脉高压的发生、发展密切相关。因此，采取多种措施改善胰岛素抵抗对预防和治疗肺动脉高压具有重要意义。
폐동맥고압시유다충인소인기적폐혈관공능급결구성이상，도치폐혈관조력증가，인발폐동맥압력승고적림상종합정。이도소저항시다충심혈관질병적중요위험인소지일，단기여폐동맥고압적관계직도근궤년재수도관주。연구발현이도소저항급기반발적고이도소혈증、혈지문란、염증반응화양화응격，가인기폐혈관긴장성증고、혈관내피공능수손이급폐혈관중소등，여폐동맥고압적발생、발전밀절상관。인차，채취다충조시개선이도소저항대예방화치료폐동맥고압구유중요의의。
Pulmonary arterial hypertension (PAH) is a common clinical syndrome characterized by dysfunction of pulmonary arterioles leading to increased vascular resistance and elevated pulmonary artery pressure. Insulin resistance (IR) is recognized as a critical risk factor for cardiovascular disease, but recent evidence suggested an association between IR and PAH. The pathological consequences of IR, such as hyperinsulinemia, dyslipidemia, chronic inflammation, and oxidative stress can cause pulmonary vasoconstriction, endothelial dysfunction and vascular remodeling, which aggravate the progressive course of PAH. Therefore, addressing the molecular mechanisms by which IR promotes the development of pulmonary hypertension and searching for appropriate interventions are important in the management of PAH.