中国实用神经疾病杂志
中國實用神經疾病雜誌
중국실용신경질병잡지
CHINESE JOURNAL OF PRACTICAL NERVOUS DISEASES
2015年
2期
6-8
,共3页
瑞替普酶%平均动脉压%症状性脑出血
瑞替普酶%平均動脈壓%癥狀性腦齣血
서체보매%평균동맥압%증상성뇌출혈
Reteplase%Mean arterial pressure%Symptomatic intracranial hemorrhage
目的：观察急性期脑梗死患者使用瑞替普酶（reteplase ，r‐PA ）治疗过程中不同血压对疗效的影响。方法39例超急性脑梗死患者，符合溶栓条件，美国国立卫生院神经功能缺损评分（National Institutes of Health Stroke Scale ，NIHSS）≥4分，采用r‐PA 36～54 mg行静脉溶栓治疗。动态观察患者溶栓过程中血压变化及NIHSS评分。比较2组入院时、溶栓24 h、溶栓2周后NIHSS评分和临床疗效。结果患者溶栓24 h及2周后NIHSS评分无明显差异，平均动脉压越高出血风险越大。Logistic回归分析显示，患者溶栓过程中平均动脉压≥105 mmHg（1 mmHg＝0.133 kPa）是脑梗死溶栓出血的危险因素（OR＝10.833，95％ CI＝1.974～59.461）。结论 r‐PA治疗超急性期脑梗死安全有效，能有效控制患者血压。
目的：觀察急性期腦梗死患者使用瑞替普酶（reteplase ，r‐PA ）治療過程中不同血壓對療效的影響。方法39例超急性腦梗死患者，符閤溶栓條件，美國國立衛生院神經功能缺損評分（National Institutes of Health Stroke Scale ，NIHSS）≥4分，採用r‐PA 36～54 mg行靜脈溶栓治療。動態觀察患者溶栓過程中血壓變化及NIHSS評分。比較2組入院時、溶栓24 h、溶栓2週後NIHSS評分和臨床療效。結果患者溶栓24 h及2週後NIHSS評分無明顯差異，平均動脈壓越高齣血風險越大。Logistic迴歸分析顯示，患者溶栓過程中平均動脈壓≥105 mmHg（1 mmHg＝0.133 kPa）是腦梗死溶栓齣血的危險因素（OR＝10.833，95％ CI＝1.974～59.461）。結論 r‐PA治療超急性期腦梗死安全有效，能有效控製患者血壓。
목적：관찰급성기뇌경사환자사용서체보매（reteplase ，r‐PA ）치료과정중불동혈압대료효적영향。방법39례초급성뇌경사환자，부합용전조건，미국국립위생원신경공능결손평분（National Institutes of Health Stroke Scale ，NIHSS）≥4분，채용r‐PA 36～54 mg행정맥용전치료。동태관찰환자용전과정중혈압변화급NIHSS평분。비교2조입원시、용전24 h、용전2주후NIHSS평분화림상료효。결과환자용전24 h급2주후NIHSS평분무명현차이，평균동맥압월고출혈풍험월대。Logistic회귀분석현시，환자용전과정중평균동맥압≥105 mmHg（1 mmHg＝0.133 kPa）시뇌경사용전출혈적위험인소（OR＝10.833，95％ CI＝1.974～59.461）。결론 r‐PA치료초급성기뇌경사안전유효，능유효공제환자혈압。
Objective To investigate the curative effect of reteplase (r‐PA) on treating blood pressure of patients with su‐per‐acute cerebral infarction. Methods 39 patients with super‐a‐cute cerebral infarction (NIHSS≥ 4 points) were treated with r‐ PA. The blood pressure changes and NIHSS score of patients were monitored during the thrombolytic therapy. The NIHSS score and curative effect of patients were compared on admission ,24 h and 2 weeks after thrombolytic therapy. Results The NIHSS score of patients at 24 h and 2 weeks after thrombolytic therapy had no significant difference ,and the higher mean arte‐rial pressure was ,the larger the bleeding risk was. Logistic regression analysis showed mean arterial blood pressure more than 105 mmHg (OR=10.833 ,95% CI=1.974 -59.461)was risk factors of patients with cerebral infarction during thrombolytic process. Conclusion r‐PA has better curative effect on treating patients with cerebral infarction and can effectively control pa‐tients’ blood pressure during thrombolytic process.
