中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2015年
2期
42-43
,共2页
慢性心力衰竭%高敏C反应蛋白%脑钠肽%疗效
慢性心力衰竭%高敏C反應蛋白%腦鈉肽%療效
만성심력쇠갈%고민C반응단백%뇌납태%료효
Chronic heart failure%High-sensitivity C-reactive protein%Brain natriuretic peptide%Efifcacy
目的:观察贝那普利对慢性心力衰竭患者疗效及血浆脑钠素(BNP)、高敏C反应蛋白(hs-CRP)水平的影响。方法选择2011年1月至2014年1月在我院就诊的慢性心力衰竭的患者80例,随机将患者分为观察组和对照组,每组各40例。对照组予以常规治疗,观察组在对照组基础上予以贝那普利治疗,观察治疗后的疗效,及治疗前后左室收缩末期容积(LVESd),左室射血分数(LVEF),左室舒张末期容积(LVEDd),6 min步行试验(6MWT),BNP和hs-CRP水平的变化。结果观察组的总有效率为97.50%明显优于对照组的80.00%,差异有统计学意义(χ2=4.507,P<0.05)。治疗后LVEDd,LVESd,6MWT,BNP和hs-CRP水平均较治疗前明显降低(P<0.01),观察组的降低水平更为明显(P<0.01);而LVEF水平均较治疗前明显升高(P<0.01),观察组的升高水平更为明显(P<0.01)。结论贝那普利对慢性心力衰竭患者疗效显著,具有改善心功能,抑制机体的炎症,值得在临床推广应用。
目的:觀察貝那普利對慢性心力衰竭患者療效及血漿腦鈉素(BNP)、高敏C反應蛋白(hs-CRP)水平的影響。方法選擇2011年1月至2014年1月在我院就診的慢性心力衰竭的患者80例,隨機將患者分為觀察組和對照組,每組各40例。對照組予以常規治療,觀察組在對照組基礎上予以貝那普利治療,觀察治療後的療效,及治療前後左室收縮末期容積(LVESd),左室射血分數(LVEF),左室舒張末期容積(LVEDd),6 min步行試驗(6MWT),BNP和hs-CRP水平的變化。結果觀察組的總有效率為97.50%明顯優于對照組的80.00%,差異有統計學意義(χ2=4.507,P<0.05)。治療後LVEDd,LVESd,6MWT,BNP和hs-CRP水平均較治療前明顯降低(P<0.01),觀察組的降低水平更為明顯(P<0.01);而LVEF水平均較治療前明顯升高(P<0.01),觀察組的升高水平更為明顯(P<0.01)。結論貝那普利對慢性心力衰竭患者療效顯著,具有改善心功能,抑製機體的炎癥,值得在臨床推廣應用。
목적:관찰패나보리대만성심력쇠갈환자료효급혈장뇌납소(BNP)、고민C반응단백(hs-CRP)수평적영향。방법선택2011년1월지2014년1월재아원취진적만성심력쇠갈적환자80례,수궤장환자분위관찰조화대조조,매조각40례。대조조여이상규치료,관찰조재대조조기출상여이패나보리치료,관찰치료후적료효,급치료전후좌실수축말기용적(LVESd),좌실사혈분수(LVEF),좌실서장말기용적(LVEDd),6 min보행시험(6MWT),BNP화hs-CRP수평적변화。결과관찰조적총유효솔위97.50%명현우우대조조적80.00%,차이유통계학의의(χ2=4.507,P<0.05)。치료후LVEDd,LVESd,6MWT,BNP화hs-CRP수평균교치료전명현강저(P<0.01),관찰조적강저수평경위명현(P<0.01);이LVEF수평균교치료전명현승고(P<0.01),관찰조적승고수평경위명현(P<0.01)。결론패나보리대만성심력쇠갈환자료효현저,구유개선심공능,억제궤체적염증,치득재림상추엄응용。
Objective To observe the efficacy of benazepril in patients with chronic heart failure and their impact on the levels of brain natriuretic peptide(BNP), high-sensitivity C-reactive protein (hs-CRP). Methods 80 patients with chronic heart failure, from January 2011 to January 2014, were randomly divided into observation group and control group, each group had 40 cases. The control group received conventional treatment, observation group were gave benazepril in the basis of the control group, the efifcacy after treatment, and the levels of left ventricular end-systolic volume(LVESd), left ventricular ejection fraction(LVEF), left ventricular end diastolic diameter (LVEDd), 6 min walk test (6MWT), BNP and hs-CRP before and after treatment were observed in each groups. Results The total effective rate was 97.50%in observation group signiifcantly better than 80.00%in control group, the difference was statistically signiifcant(χ2=4.507, P<0.05). After treatment, the levels of LVEDd, LVESd, 6MWT, BNP and hs-CRP were signiifcantly lower than those before treatment(P<0.01), lower levels in observation group were more obvious(P<0.01);while, the levels of LVEF were signiifcantly higher compared with those before treatment(P<0.01), the elevated levels were more obvious in observation group(P<0.01). Conclusion The efifcacy of benazepril in patients with chronic heart failure is obvious, with improved cardiac function and inhibitory body's inlfammation, it is worthy of clinical application.