中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2015年
2期
19-19,20
,共2页
丁娟%许晶晶%罗鹏%罗俏燕
丁娟%許晶晶%囉鵬%囉俏燕
정연%허정정%라붕%라초연
糖尿病,2型%血糖控制%地特胰岛素%门冬胰岛素%预混胰岛素类似物
糖尿病,2型%血糖控製%地特胰島素%門鼕胰島素%預混胰島素類似物
당뇨병,2형%혈당공제%지특이도소%문동이도소%예혼이도소유사물
Type 2 Diabetes%Glycemic control%Insulin detemir%Insulin aspart%Premixed insulin analogue
目的:观察口服降糖药(OAD)血糖控制不佳的T2DM患者,分别采用地特胰岛素联合门冬胰岛素和预混胰岛素类似物强化治疗的有效性、安全性。方法选取OAD血糖控制不佳的T2DM患者92例随机分为地特胰岛素联合门冬胰岛素(A组)和预混胰岛素类似物(B组)强化治疗4周。结果4周后,两组治疗前后FBG、2 hPG、HbA1c均较基线显著降低(P<0.05),而组间血糖达标时间、达标时胰岛素用量、低血糖发生率差异无统计学意义(P>0.05)。结论地特胰岛素联合门冬胰岛素与预混胰岛素类似物均可有效控制OAD控制不佳的T2DM患者血糖,且低血糖发生率低,安全性高。
目的:觀察口服降糖藥(OAD)血糖控製不佳的T2DM患者,分彆採用地特胰島素聯閤門鼕胰島素和預混胰島素類似物彊化治療的有效性、安全性。方法選取OAD血糖控製不佳的T2DM患者92例隨機分為地特胰島素聯閤門鼕胰島素(A組)和預混胰島素類似物(B組)彊化治療4週。結果4週後,兩組治療前後FBG、2 hPG、HbA1c均較基線顯著降低(P<0.05),而組間血糖達標時間、達標時胰島素用量、低血糖髮生率差異無統計學意義(P>0.05)。結論地特胰島素聯閤門鼕胰島素與預混胰島素類似物均可有效控製OAD控製不佳的T2DM患者血糖,且低血糖髮生率低,安全性高。
목적:관찰구복강당약(OAD)혈당공제불가적T2DM환자,분별채용지특이도소연합문동이도소화예혼이도소유사물강화치료적유효성、안전성。방법선취OAD혈당공제불가적T2DM환자92례수궤분위지특이도소연합문동이도소(A조)화예혼이도소유사물(B조)강화치료4주。결과4주후,량조치료전후FBG、2 hPG、HbA1c균교기선현저강저(P<0.05),이조간혈당체표시간、체표시이도소용량、저혈당발생솔차이무통계학의의(P>0.05)。결론지특이도소연합문동이도소여예혼이도소유사물균가유효공제OAD공제불가적T2DM환자혈당,차저혈당발생솔저,안전성고。
Objective To investigate the effectiveness and safety of insulin detemir combined with insulin aspart regimens versus premixed insulin analogue regimens for treating patients with type 2 diabetes in poorglycemic control starting therapy with oral antidiabetic drugs. Methods Ninety-two cases of type 2 diabetes patients who still had poor glycemic control by treatment of OAD were randomized to insulin detemir combined with insulin aspart group(group A)or premixed insulin analogue group(group B). Patients were received intensive therapy for 4 weeks. Results After 4 weeks treatment, the levels of fasting blood glucose(FBG), 2-hour postprandial blood glucose(2hPG)and glycated hemoglobin(HbA1c)decreased signiifcantly from baseline (P<0.05)in both groups. However, there were no signiifcant differences(P>0.05)in the recovering time of blood glucose, insulin dose and rate of hypoglycemia between two groups. Conclusion Both the treatment of insulin detemir combined with insulin aspart and premixed insulin analogue are safe and effective in controlling the level of blood glucose, and rates of hypoglycemia are low in patients with T2DM who had poor glycemic control by treatment of OAD.