CAJ | 학술논문

孕激素是一种免疫调节分子，它主要通过与孕激素受体结合发挥免疫调节作用。大量研究证实，孕激素受体在多种淋巴细胞表达，孕激素在免疫调节中可诱导 Th2细胞反应，抑制 Th1细胞反应，抑制巨噬-单核细胞、自然杀伤细胞的杀伤活力。血清孕激素水平降低，孕激素受体表达调节障碍将影响自身免疫功能的调节，导致自身免疫性疾病的发生和发展。
잉격소시일충면역조절분자，타주요통과여잉격소수체결합발휘면역조절작용。대량연구증실，잉격소수체재다충림파세포표체，잉격소재면역조절중가유도 Th2세포반응，억제 Th1세포반응，억제거서-단핵세포、자연살상세포적살상활력。혈청잉격소수평강저，잉격소수체표체조절장애장영향자신면역공능적조절，도치자신면역성질병적발생화발전。
Progesterone is an immunomodulatory molecule,its major immunomodulatory activities are mediated and then produced by progesterone in combination with related receptors.Numerous studies have been confirmed that progesterone receptor expressed in multiple lymphocytes,the immunomodulatory activities of progesterone are able to induce Th2 cell re-sponse,and inhibit Th1 cell response,as well as suppress killing activities from NK cell and macrophage /monocyte.Lower level of progesterone in sera and impaired progesterone receptor expression have been identified in autoimmune diseases, which may result in an attenuation in the immunomodulatory effect of progesterone,and contribute to the initiation and pro-gression of autoimmune diseases.