CAJ | 학술논문

大气细颗粒物（PM2．5）能够深入下呼吸道，直达肺泡，并且能透过肺呼吸道屏障，进入循环系统，随血流而到达全身各靶器官，对其组织细胞造成伤害。除诱发呼吸系统疾病外，PM2．5还能致心血管疾病、糖尿病、恶性肿瘤等多种疾病的发生和发展。PM2．5致局部组织或系统的急性或慢性炎症、炎症细胞的浸润、炎症因子的异常表达与释放等，被认为是致人体健康损伤的重要机制。在综述 PM2．5与炎症细胞的相互作用、炎症因子的表达与释放等致炎症效应新成果的基础上，概述了近年来人们对于 PM2．5致炎症作用机制的新认识。
대기세과립물（PM2．5）능구심입하호흡도，직체폐포，병차능투과폐호흡도병장，진입순배계통，수혈류이도체전신각파기관，대기조직세포조성상해。제유발호흡계통질병외，PM2．5환능치심혈관질병、당뇨병、악성종류등다충질병적발생화발전。PM2．5치국부조직혹계통적급성혹만성염증、염증세포적침윤、염증인자적이상표체여석방등，피인위시치인체건강손상적중요궤제。재종술 PM2．5여염증세포적상호작용、염증인자적표체여석방등치염증효응신성과적기출상，개술료근년래인문대우 PM2．5치염증작용궤제적신인식。
Airborne fine particulate matter (PM2.5 )can not only deeptly come into the respiratory tract and directly access to the alveoli,but also penetrate the breathing protective screen in lungs,then enter into the circulatory system,finally ar-rive at the target organ and damage the tissue cells.PM2.5 can also induce the occurrence and development of respiratory system diseases,diabetes,cardiovascular diseases,malignant tumors and so on.The acute or chronic inflammation of local tissue or system,infiltration by inflammatory cell and abnormal expression and release of inflammatory factor is considered to be the important mechanism in damaging to human health induced by PM2.5 .This review is based on the new achieve-ments of inflammatory effects,including the interaction of PM2.5 and inflammatory cells,expression and release of inflam-matory cytokine,summarize advances on the inflammatory mechanisms induced by PM2.5 in recent years.