CAJ | 학술논문

目的：观察冷冻新鲜芦荟漱口液预防造血干细胞移植患者并发口腔黏膜炎的效果。方法选取2013年1月—2014年1月42例接受造血干细胞移植的恶性血液病患者作为研究对象。按照随机数字表法将患者分为研究组20例和对照组22例。对照组使用常规口腔干预方法，研究组在常规口腔干预方法的基础上增加冷冻新鲜芦荟漱口液漱口，取新鲜库拉索芦荟或中华芦荟约30～40 g洗净，去刺及表皮后，将果冻状部分放入100℃的250 ml开水中泡制，待溶液冷却后放入2～4℃的冰箱冷冻6～8h后用于患者漱口。比较两组患者口腔黏膜炎发生程度。结果研究组发生口腔黏膜炎0级11例，Ⅰ级6例，Ⅱ级2例，Ⅲ级1例，对照组分别为5，3，10，4例，两组比较差异有统计学意义（ U＝112．5，P＜0．01）。结论冷冻新鲜芦荟漱口液在预防造血干细胞移植患者并发口腔黏膜炎方面有一定疗效，且经济有效。
목적：관찰냉동신선호회수구액예방조혈간세포이식환자병발구강점막염적효과。방법선취2013년1월—2014년1월42례접수조혈간세포이식적악성혈액병환자작위연구대상。안조수궤수자표법장환자분위연구조20례화대조조22례。대조조사용상규구강간예방법，연구조재상규구강간예방법적기출상증가냉동신선호회수구액수구，취신선고랍색호회혹중화호회약30～40 g세정，거자급표피후，장과동상부분방입100℃적250 ml개수중포제，대용액냉각후방입2～4℃적빙상냉동6～8h후용우환자수구。비교량조환자구강점막염발생정도。결과연구조발생구강점막염0급11례，Ⅰ급6례，Ⅱ급2례，Ⅲ급1례，대조조분별위5，3，10，4례，량조비교차이유통계학의의（ U＝112．5，P＜0．01）。결론냉동신선호회수구액재예방조혈간세포이식환자병발구강점막염방면유일정료효，차경제유효。
Objective To observe the prevention effect of frozen fresh aloe mouthwash on oral cavity mucous membrane inflammation in patients with hematopoietic stem cell transplantation, so as to find an economic and effective method for prevention the oral mucosa inflammation.Methods A total of 42 patients were admitted in our hospital from January 2013 to January 2014.They were divided into the experimental group (20 cases) and the control group (22 cases).The control group was given the conventional oral intervention measures.On the basis of it, the experimental group was given frozen fresh aloe mouthwash, with fresh Curacao aloe vera 30 to 40 gram, peeled its thorn, and put in the 250 ml boiled water (100℃).After cooling down, it was stored for 6 to 8 hours in the 2 -4 ℃ refrigerator.The degree of oral mucositis of the two groups was compared.Results In the experimental group, eleven patients had 0 degree of oral mucositis, six patients hadⅠdegree of oral mucositis, two patients had Ⅱdegree of oral mucositis, one patient had Ⅲ degree of oral mucositis.Those numbers of patients in the control group were five, three, ten, four, respectively.There was a significant difference between two groups (U=112.5,P<0.01).Conclusions Frozen fresh aloe mouthwash can prevent oral mucositis among patients with hematopoietic stem cell transplantation.It is easy for patients to accept, and it is economic and effective.