CAJ | 학술논문

β-arrestins是在提纯β-肾上腺素受体激酶(β-adrener-gic receptor kinase,β-ARK)的过程中发现的一类重要的接头蛋白和信号调控蛋白,对绝大部分G蛋白偶联受体( G pro-tein-coupled receptor,GPCR)介导的信号转导都具有调节作用。纤维化疾病如肝纤维化、肺纤维化、心血管纤维化等,其发病因素和临床表现各不相同,但最终的病理特征都是细胞外基质(extracellular matrix,ECM)在组织器官内过度沉积。大量研究表明,β-arrestins 在纤维化疾病的炎症反应、ECM沉积等作用中发挥重要作用,该文就β-arrestins在纤维化疾病中的研究现状和发展前景作一综述。
β-arrestins시재제순β-신상선소수체격매(β-adrener-gic receptor kinase,β-ARK)적과정중발현적일류중요적접두단백화신호조공단백,대절대부분G단백우련수체( G pro-tein-coupled receptor,GPCR)개도적신호전도도구유조절작용。섬유화질병여간섬유화、폐섬유화、심혈관섬유화등,기발병인소화림상표현각불상동,단최종적병리특정도시세포외기질(extracellular matrix,ECM)재조직기관내과도침적。대량연구표명,β-arrestins 재섬유화질병적염증반응、ECM침적등작용중발휘중요작용,해문취β-arrestins재섬유화질병중적연구현상화발전전경작일종술。
β-arrestins, a kind of important adaptor protein and signal transduction protein found in the purification process ofβ-adrenergic receptor kinase (β-ARK) ,were first identified as pro-teins that have the ability to desensitize G protein-coupled recep-tors ( GPCR) . Fibrosis is defined by the overgrowth, hardening, and scarring of various tissues and is attributed to excess deposi-tion of extracellular matrix ( ECM ) components including colla-gen . A large number of studies have shown thatβ-arrestins play an important role in the process of fibrotic diseases, involved in inflammatory response and excess deposition of ECM. This re-view discusses the research status and development prospects ofβ-arrestins-mediated fibrotic diseases.